Apolipoprotein E Knockout Models

Title: Apolipoprotein E Knockout Models

Volume: 14 Issue: 4

Author(s): Genovefa Kolovou, Katherine Anagnostopoulou, Dimitri P. Mikhailidis and Dennis V. Cokkinos

Affiliation:

Keywords: Apolipoprotein E, knock out, atherosclerosis

Abstract: Atherosclerosis is a multifactorial and long-lasting process in humans. Therefore, animal models where more rapid changes occur can be useful for the study of this process. Among such models are the apolipoprotein (apo) E knock out mice. Apo E deficient mice show impaired clearing of plasma lipoproteins and they develop atherosclerosis in a short time. The current review considers lipid metabolism and inflammation as well as nutritional and pharmacological agents affecting atherosclerosis, using the apo E knock out mouse model.

Cite this article as:

Kolovou Genovefa, Anagnostopoulou Katherine, Mikhailidis P. Dimitri and Cokkinos V. Dennis, Apolipoprotein E Knockout Models, Current Pharmaceutical Design 2008; 14 (4) . https://dx.doi.org/10.2174/138161208783497769