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Current Organic Synthesis

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ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

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Mini-Review Article

Recent Advances in Metal-Catalyzed Heterocyclic C-P Bond Formation

Author(s): Feng Xu* and Yu Hui

Volume 18, Issue 4, 2021

Published on: 28 December, 2020

Page: [377 - 387] Pages: 11

DOI: 10.2174/1570179417999201228214930

Price: $65

Abstract

The phosphorus-containing heterocycles are an important class of compounds in organic chemistry. Because of their potential application in many fields, especially, the synthetic pesticides, medicine and catalyst, the phosphorus-containing heterocycles have attracted continuous attention from organic synthesis scientists. The development of efficient and low-cost catalytic systems is of great interest for the construction of heterocycles C-P bond. Usually, the phosphorus-containing heterocycles is prepared via direct carbon–hydrogen (C-H) bond activation or pre-functionalized of heterocycles with phosphorus-hydrogen (P-H) bond of phosphorus compounds reaction by metal-catalyzed. This review summarizes recent progress in the heterocycles C-P bond formation reactions by metal-catalyzed, which mainly focus on the discussion of the reaction mechanism. It aims to provide efficient methods for the future synthesis and application in this field.

Keywords: Phosphorus-containing heterocycles, metal-catalyzed, C-P bond, cross-coupling reaction, C-H bond activation, radical addition.

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