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Review Article

Blood Cell Count Indexes of Systemic Inflammation in Carotid Artery Disease: Current Evidence and Future Perspectives

Author(s): Paola Dettori, Panagiotis Paliogiannis*, Rosa M. Pascale, Angelo Zinellu, Arduino A. Mangoni and Gianfranco Pintus

Volume 27, Issue 18, 2021

Published on: 22 December, 2020

Page: [2170 - 2179] Pages: 10

DOI: 10.2174/1381612826666201222155630

Price: $65

Abstract

Carotid artery disease is commonly encountered in clinical practice and accounts for approximately 30% of ischemic strokes in the general population. Numerous biomarkers have been investigated as predictors of the onset and progression of carotid disease, the occurrence of cerebrovascular complications, and overall prognosis. Among them, blood cell count (BCC) indexes of systemic inflammation might be particularly useful, from a pathophysiological and clinical point of view, given the inflammatory nature of the atherosclerotic process. The aim of this review is to discuss the available evidence regarding the role of common BCC indexes, such as the neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR), platelet to lymphocyte ratio (PLR), mean platelet volume (MPV), platelet distribution width (PDW), and red cell distribution width (RDW), in the diagnosis and risk stratification of carotid artery disease, and their potential clinical applications.

Keywords: Carotid artery disease, atherosclerosis, NLR, PLR, MLR, RDW, MPV.

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