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Mini-Review Article

Past and Present Behçet’s Disease Animal Models

Author(s): Jermilia Charles, Francis J. Castellino and Victoria A. Ploplis*

Volume 21, Issue 16, 2020

Page: [1652 - 1663] Pages: 12

DOI: 10.2174/1389450121666200719010425

Price: $65

Abstract

Behçet’s disease (BD) is presumably an autoinflammatory disease of unknown etiology for which several animal models have been described over the years. Agents and methods used for the development of these models have ranged from the herpes simplex type one virus (hsv-1) pathogen to the use of transgenic mice. Other models have also been used to investigate a possible autoimmune component. Each model possesses its own unique set of benefits and shortcomings, with no one model fully being able to recapitulate the disease phenotype. Here, we review the proposed models and provide commentary on their effectiveness and usefulness in studying the disease.

Keywords: Behçet’s disease (BD), rare disease, Behçet’s disease animal models, autoimmune disease, herpes simplex virus type 1, human leukocyte antigen.

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