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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

阿尔茨海默氏病患者氧化应激与胆固醇代谢改变之间的关联

卷 17, 期 9, 2020

页: [823 - 834] 页: 12

弟呕挨: 10.2174/1567205017666201203123046

价格: $65

摘要

背景：氧化应激是包括阿尔茨海默氏病（AD）在内的多种疾病的主要特征。最近报道了氧固醇衍生物的参与。 目的：本研究的目的是评估氧化应激对AD患者胆固醇损伤的影响。 方法：对56例AD患者和97例对照进行了病例对照研究。用分光光度法对红细胞（RBC）和血浆进行了氧化生物标记物水平的测定，包括脂质过氧化产物和抗氧化酶活性。胆固醇前体和氧固醇（7-酮胆固醇（7KC），7α-羟基胆固醇（7α-OHC），7β-羟基胆固醇（7β-OHC），24S-羟基胆固醇（24S-OH），25-羟基胆固醇（25-OHC）和27-羟基胆固醇通过气相色谱-质谱法定量测定血浆中的（27-OHC）。 结果：在AD患者的RBC和血浆中，发现谷胱甘肽过氧化物酶（GPx）活性显着下降与丙二醛（MDA）水平升高相关。在AD患者中，与对照组相比，血浆AD患者血浆中的羊毛甾醇水平降低和7β-OHC，24S-OHC，27-OHC和25-OHC的积累也较高。小精神状态检查（MMSE）得分与血浆中的MDA和共轭二烯（CD）水平相关。此外，红细胞中的MDA水平与7β-OHC相关。二元逻辑回归显示GPx活性与AD之间存在关联（OR = 0.895，95％CI：0.848-0.945。P <0.001）。 结论：我们的数据巩固了AD中氧化还原稳态的破裂与脂质和胆固醇氧化之间的关系。

关键词: 阿尔茨海默氏病，氧化应激，氧固醇，脂质过氧化，抗氧化酶，胆固醇。

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