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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Review Article

非甾体类抗炎药可作为预防或治疗阿尔茨海默氏病的候选药物：它们仍然发挥作用吗？

卷 17, 期 11, 2020

页: [1013 - 1022] 页: 10

弟呕挨: 10.2174/1567205017666201127163018

价格: $65

摘要

审查目的：提供有关非甾体类抗炎药（NSAID）作为阿尔茨海默氏病（AD）治疗方法的最新分析。 最新发现：AD的神经炎症是一个活跃的研究领域，基础和临床研究越来越多的证据表明先天性或适应性免疫应答参与了AD的病理生理。在过去的十年中，几乎没有进行过抗炎药的临床试验，但结果都是负面的。 摘要：除了从基础研究中收集的信息外，流行病学研究还提供了相互矛盾的发现，大多数病例对照或患病率研究表明，NSAIDs的使用与AD之间存在反比关系，但在基于人群的前瞻性事件队列研究中，结果却存在分歧。使用不同的NSAID进行的临床试验几乎一致报告了AD缺乏明显益处。 结论：炎症反应的调节是AD中一种有希望的治疗策略。经过三十年的研究，似乎常规的非甾体抗炎药不是最佳的药理学选择，因为它们缺乏明确的作用，并且长期治疗中不利的副作用。其他抗炎药作为AD治疗的候选药物的开发可能会受益于NSAID获得的知识。

关键词: 非甾体抗炎药，淀粉样蛋白，阿尔茨海默氏病，风险，临床试验，抗炎药。

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