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Review Article

改变吖啶黄素的用途以靶向治疗慢性髓系白血病

卷 28, 期 11, 2021

发表于: 08 September, 2020

页: [2218 - 2233] 页: 16

弟呕挨: 10.2174/0929867327666200908114411

价格: $65

摘要

药物再利用最近在一些疾病特别是癌症中获得了越来越多的关注，因为它的优点是通过采用成本友好的方法，避免了严格的食品和药物管理局(FDA)的规定，促进了新的治疗策略的发展。吖黄素(ACF)是FDA批准的一种分子，自1912年以来被广泛研究，具有杀菌、锥虫、抗病毒、抗菌和抗癌作用。ACF已被证明可以阻断实体和造血肿瘤细胞的生长。事实上，ACF作为多种蛋白质的抑制剂，包括DNA依赖蛋白激酶C (DNA-PKcs)，拓扑异构酶I和II，缺氧诱导因子1α (HIF-1α)，以及最近发现的信号转导抑制剂和转录激活因子(STAT)。慢性髓系白血病(Chronic myeloid leukemia, CML)是一种克隆性骨髓增生性疾病，其特征是表达组成型活性酪氨酸激酶BCR-ABL。该蛋白可以激活几个在细胞增殖和存活中发挥作用的信号通路，如JAK/STAT通路。CML治疗，基于酪氨酸激酶抑制剂(TKIs)，如伊马替尼(IM)，是非常有效的。然而，15%的患者对IM是难治性的，在某些情况下，20-30%的患者变得耐药。因此，我们建议在IM失败后改变ACF在CML中的用途或联合IM来提高IM的抗肿瘤作用。在这篇综述中，我们介绍了ACF的不同药理特性及其抗白血病作用，希望它在CML治疗中的重新利用。

关键词: 吖啶黄，ACF，药物再利用，慢性髓系白血病，白血病，抗肿瘤，抗白血病

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