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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Systematic Review Article

系统综述：轻度认知损伤和早期阿尔茨海默病认知训练研究的神经影像学结果

卷 17, 期 5, 2020

页: [472 - 486] 页: 15

弟呕挨: 10.2174/1567205017666200624202425

价格: $65

摘要

背景:认知训练(CT)已证明对轻度认知障碍(MCI)和早期痴呆患者的认知和心理社会功能有一定的好处，但这些发现的确定性仍不清楚。因此，了解CT改善认知功能的机制有助于理解CT与认知功能的关系。本综述的目的是确定MCI和早期阿尔茨海默病(AD) 的CT研究中神经影像学结果的证据。 方法:采用预先设定的搜索策略，搜索Medline、Embase、Web of Science、PsycINFO、CINAHL和Cochrane图书馆，共获得1778篇文章。对MCI或AD患者使用CT程序，并将有结构或功能的磁共振成像(MRI)结果纳入研究。使用Downs和Black标准对研究的质量进行评估。 结果:共有19项研究符合纳入标准。纳入研究的质量是可变的，纳入本综述的研究存在显著的异质性。训练后，任务激活度普遍增加，但功能连接度在训练后既增加又减少。结果因诊断、CT程序类型和脑网络检查而异。训练后海马体积未见影响，但皮质增厚和灰质体积增加。 结论:CT可导致痴呆患者功能和结构变化，但异质性和研究质量限制了结论的准确性。需要更大规模、更有力的研究来将这些发现与CT的临床益处联系起来。

关键词: 认知障碍，脑训练，脑成像，MCI，阿尔茨海默病，血管性认知功能障碍。

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