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Mini-Review Article

RNA细胞靶向配体用于口腔黏膜免疫的现状c

卷 21, 期 12, 2020

页: [1276 - 1284] 页: 9

弟呕挨: 10.2174/1389450121666200609113252

价格: $65

摘要

免疫系统在预防感染中起着重要作用，是抵御病原体攻击的第一道防线。由于黏膜表面是病原体最常见的进入部位，通过黏膜途径传递抗原可能会诱发黏膜免疫系统。黏膜免疫系统将有能力对抗黏膜表面的病原体。口腔黏膜免疫打开了在肠道相关淋巴组织传递抗原的途径。这会引起局部和全身的免疫反应。黏膜疫苗经济、容易获得、非肠外接种和在大流行时产生大规模免疫接种能力。免疫系统依靠特殊的上皮细胞即微褶(M)细胞在胃肠道黏膜表面传递抗原。利用M细胞上的靶向特异性受体进入抗原的方法在疫苗研制中取得了突破性进展。在这篇综述中，各种策略已经讨论了抗原可能通过M细胞进入和增加口服黏膜免疫疫苗的摄取和效果的方法。

关键词: 口腔黏膜免疫，M细胞，内脏相关淋巴组织， 派尔集合淋巴结

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