Abstract
Background: Solubility is one of the significant pre-formulation properties which regulate the desired concentration of drug in the systemic circulation. Most of the newly discovered chemical entities show poor solubility which consequently leads to poor bioavailability. To enhance the bioavailability of such type of drugs is a big challenge for pharmaceutical scientists. Liquisolid technology is a new and advanced technology used to transform the liquid medication into dry, free-flowing and easily compressible dosage form incorporation with the carrier and coating material.
Objectives: This review represents the technical perspective of Liquisolid technologies that overcome the demerits of classic formulation strategies and amend the bioavailability of the poorly soluble drug. This technique is also approaches the stability, hygroscopicity and agglomeration issue which are mainly occurring in other techniques for solubility enhancement.
Conclusion: Several technologies have been utilized to minimize the solubility problem but due to the complicated and expensive machinery fails to achieve the desired bioavailability of the poorly soluble drugs. Therefore, Liquisolid technology has been introduced as an innovative and promising technique that recovers the demerits of classic formulation strategies and also improves the bioavailability of the poorly soluble drug. This article exhibits the technical approach of the liquisolid system by improving the solubility as well as bioavailability of water-insoluble drugs.
Keywords: Solubility, liquisolid, dissolution, bioavailability, poorly soluble drugs, hygroscopicity.
Graphical Abstract
[1]
Sandhiya, J.; Avtar, C.R.; Gurpreet, S.; Geeta, A. An overview on solubility enhancement (Technique for poorly soluble drugs and solid dispersion as eminent strategic approach). Int. J. Pharm. Sci. Res., 2012, 3, 942-956.
[2]
Kadam, S.V.; Shinkar, D.M.; Saudagar, R.B. Review on solubility enhancement technique. Int. J. Pharma Bio Sci., 2013, 3, 462-475.
[3]
Lipinski, C.A.; Lombardo, F.; Dominy, B.W.; Feeney, P.J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev., 2001, 46(1-3), 3-26.
[http://dx.doi.org/10.1016/S0169-409X(00)00129-0] [PMID: 11259830]
[http://dx.doi.org/10.1016/S0169-409X(00)00129-0] [PMID: 11259830]
[4]
Varun, R.V.; Venkateshwarlu, L.; Srikanth, L. Solubility enhancement technique. Int. J. Pharm. Sci. Rev. Res., 2010, 5, 1-21.
[5]
Yogesh, S.T.; Indrajeet, D.G.; Avinash, H.H. Solubility enhancement technique: a review on conventional and novel approaches. Int. J. Pharm. Sci. Res., 2011, 2, 2501-2513.
[6]
Kisor, S. Gavhane, Dr.Sayyad, F.J.; Kishor. Liquisolid compact: a review. Int. J. Pharm. Bio. Res., 2013, 4, 1-6.
[8]
Sameer, S.; Raviraj, S.B.; Lalit, Y. Singh. A review on solid dispersion method. Int. J. Pharm. Life Sci., 2011, 2, 1078-1095.
[9]
Abolghasem, J. Review of the co-solvency models for predicting solubility of drugs in water, co solvent mixtures. J. Pharm. Pharm. Sci., 2008, 11, 32-58.
[http://dx.doi.org/10.18433/J3PP4K]
[http://dx.doi.org/10.18433/J3PP4K]
[10]
Serajuddin, A.T. Salt formation to improve drug solubility. Adv. Drug Deliv. Rev., 2007, 59(7), 603-616.
[http://dx.doi.org/10.1016/j.addr.2007.05.010] [PMID: 17619064]
[http://dx.doi.org/10.1016/j.addr.2007.05.010] [PMID: 17619064]
[11]
Nokhodchi, A.; Hentzschel, C.M.; Leopold, C.S. Drug release from liquisolid systems: speed it up, slow it down. Expert Opin. Drug Deliv., 2011, 8(2), 191-205.
[http://dx.doi.org/10.1517/17425247.2011.548801] [PMID: 21222556]
[http://dx.doi.org/10.1517/17425247.2011.548801] [PMID: 21222556]
[12]
Bhumi, B.P.; Chainesh, N.S. Recent research on liquisolid technology for solubility enhancement-A review. Int. J. Adv. Pharm., 2016, 5, 2320-4923.
[13]
Chande, P.; Raj, K. Kapoor, A. Liquisolid technique: an Approaches for enhancement of solubility. J. Drug Deliv. Ther., 2013, 3, 131-137.
[14]
Alam, M.A.; Al-Jenoobi, F.I.; Al-Mohizea, A.M. Commercially bioavailable proprietary technologies and their marketed products. Drug Discov. Today, 2013, 18(19-20), 936-949.
[http://dx.doi.org/10.1016/j.drudis.2013.05.007] [PMID: 23707660]
[http://dx.doi.org/10.1016/j.drudis.2013.05.007] [PMID: 23707660]
[15]
Kishor, S. Gavhane; Dr. Sayyad. Liquisolid technique: a review. Int. J. Pharm. Bio. Res., 2013, 4, 26-31.
[16]
Mei, L.A.; Haonan, X.A.; Jingzheng, J.A.; Xiao, C.A.; Tianzhi, Y.B.; Dongkai, W.A.; Pingtian, D. Liquisolid technique and its applications in pharmaceutics. Asian. J. Pharm. Sci., 2016, 9, 1-9.
[17]
Nikhil, B.S.; Sheetal, B. Gondkar, Ravindranath, B.; Saudagar. Liquisolid system: solubility enhancement of poor soluble drugs. World. J. Pharm. Res., 2015, 4, 1748-1765.
[18]
Kala, N.P.; Shaikh, M.T.; Shastri, D.H.; Shelat, P.K. Liquisolid compact: a review. J. Drug Deliv. Ther., 2014, 4, 25-31.
[http://dx.doi.org/10.22270/jddt.v4i3.828]
[http://dx.doi.org/10.22270/jddt.v4i3.828]
[19]
Leila, A.B.; Javad, S.; Khosro, A.; Javadzadeh, Y. Liquisolid technology: what it can do for NSAIDs delivery? Colloids. Sur. Bioint., 2015, 9, 1-24.
[20]
Sudarshan, B.A.; Dattatraya, M.S.; Ravindra, B.S.; Sudarshan, B.A. Liquisolid dosage system: a novel approach for dosage formulation. Int. J. Pharm. Sci. Res., 2015, 6, 74-79.
[21]
Anna, B.; Umasankhar, M.S.M.S.; Kavitha, B. Liquisolid technology- a latest review. Int. J. App. Pharm., 2014, 6, 1-30.
[23]
Spireas, S.S.; Jarowski, C.I.; Rohera, B.D. Powdered solution technology: principles and mechanism. Pharm. Res., 1992, 9(10), 1351-1358.
[http://dx.doi.org/10.1023/A:1015877905988] [PMID: 1448438]
[http://dx.doi.org/10.1023/A:1015877905988] [PMID: 1448438]
[25]
Tayel, S.A.; Soliman, I.I.; Louis, D. Improvement of dissolution properties of carbamazepine through application of the liquisolid tablet technique. Eur. J. Pharm. Biopharm., 2008, 69(1), 342-347.
[http://dx.doi.org/10.1016/j.ejpb.2007.09.003] [PMID: 17949959]
[http://dx.doi.org/10.1016/j.ejpb.2007.09.003] [PMID: 17949959]
[26]
Jyotsana, R.M.; Kiran, T.P.; Kamal, D. Solubility enhancement studies on Laurasidone hydrochloride using mixed hydrotropic. Int. J. Pharm. Investig., 2015, 5, 1-27.
[27]
Chella, N.C.; Nalini, S.; Rama, R.T. Use of the Liquisolid compact technique for improvement of the dissolution rate of Valsartan. Acta Pharm. Sin. B, 2012, 2, 502-508.
[http://dx.doi.org/10.1016/j.apsb.2012.07.005]
[http://dx.doi.org/10.1016/j.apsb.2012.07.005]
[28]
Fahmy, R.H.; Kassem, M.A. Enhancement of famotidine dissolution rate through liquisolid tablets formulation: in vitro and in vivo evaluation. Eur. J. Pharm. Biopharm., 2008, 69(3), 993-1003.
[http://dx.doi.org/10.1016/j.ejpb.2008.02.017] [PMID: 18396390]
[http://dx.doi.org/10.1016/j.ejpb.2008.02.017] [PMID: 18396390]
[29]
Tekade, B.W.; Jadhao, U.T.; Patil, V.R.; Sumit, D. Formulation and evaluations of Chlorphenramine maleate fast dissolving film as an anti allergic medication. Eur. J. Pharm. Med. Res., 2017, 4, 340-345.
[30]
Gubbi, S.; Jarag, R. Liquisolid technique for enhancement of dissolution properties of bromhexine hydrochloride. Res. J. Pharm Tech, 2009, 2, 382-386.
[31]
Yadav, V.B.; Yadav, A.V. Enhancement of solubility and dissolution rate of BCS class II pharmaceuticals by Non- aqueous granulation technique. Int. J. Pharm. Res. Dev., 2010, 1, 1-12.
[32]
Elkordy, A.A.; Essa, E.A.; Dhuppad, S.; Jammigumpula, P. Liquisolid technique to enhance and to sustain griseofulvin dissolution: effect of choice of non-volatile liquid vehicles. Int. J. Pharm., 2012, 434(1-2), 122-132.
[http://dx.doi.org/10.1016/j.ijpharm.2012.05.072] [PMID: 22677418]
[http://dx.doi.org/10.1016/j.ijpharm.2012.05.072] [PMID: 22677418]
[33]
Elzoghby, A.O.; Saad, N.I.; Helmy, M.W.; Samy, W.M.; Elgindy, N.A. Ionically-crosslinked milk protein nanoparticles as flutamide carriers for effective anticancer activity in prostate cancer-bearing rats. Eur. J. Pharm. Biopharm., 2013, 85(3 Pt A), 444-451.
[http://dx.doi.org/10.1016/j.ejpb.2013.07.003] [PMID: 23872177]
[http://dx.doi.org/10.1016/j.ejpb.2013.07.003] [PMID: 23872177]
[34]
Shirsand, S.B.; Para, M.S.; Nagendrakumar, D.; Kanani, K.M.; Keerthy, K. Formulation and evaluation of Ketoconazol niosomal gel drug delivery system. Int. J. Pharm. Investig., 2012, 4, 201-207.
[35]
Spireas, S.; Wang, T.; Grover, R. Effect of powder substrate on the dissolution properties of methyclothiazide liquisolid compacts. Drug Dev. Ind. Pharm., 1999, 25(2), 163-168.
[http://dx.doi.org/10.1081/DDC-100102156] [PMID: 10065349]
[http://dx.doi.org/10.1081/DDC-100102156] [PMID: 10065349]
[36]
Elkordy, A.A.; Tan, X.N.; Essa, E.A. Spironolactone release from liquisolid formulations prepared with Capryol™ 90, Solutol® HS-15 and Kollicoat® SR 30 D as non-volatile liquid vehicles. Eur. J. Pharm. Biopharm., 2013, 83(2), 203-223.
[http://dx.doi.org/10.1016/j.ejpb.2012.08.004] [PMID: 22960707]
[http://dx.doi.org/10.1016/j.ejpb.2012.08.004] [PMID: 22960707]
[37]
Spireas, S.; Sadu, S.; Grover, R. In vitro release evaluation of hydrocortisone liquisolid tablets. J. Pharm. Sci., 1998, 87(7), 867-872.
[http://dx.doi.org/10.1021/js970346g] [PMID: 9649356]
[http://dx.doi.org/10.1021/js970346g] [PMID: 9649356]
[38]
Spireas, S.; Sadu, S. Enhancement of prednisolone dissolution properties using Liquisolid compacts. Int. J. Pharm., 1998, 166, 177-188.
[http://dx.doi.org/10.1016/S0378-5173(98)00046-5]
[http://dx.doi.org/10.1016/S0378-5173(98)00046-5]
[39]
Akinlade, B.; Elkordy, A.A.; Essa, E.A.; Elhagar, S. Liquisolid systems to improve the dissolution of furosemide. Sci. Pharm., 2010, 78(2), 325-344.
[http://dx.doi.org/10.3797/scipharm.0912-23] [PMID: 21179350]
[http://dx.doi.org/10.3797/scipharm.0912-23] [PMID: 21179350]
[40]
El-Houssieny, B.M.; Wahman, L.; Arafa, N.M.S. Bioavailability and biological activity of liquisolid compact formula of repaglinide and its effect on glucose tolerance in rabbits. Biosci. Trends, 2010, 4(1), 17-24.
[PMID: 20305340]
[PMID: 20305340]
[41]
Javadzadeh, Y.; Musaalrezaei, L.; Nokhodchi, A. Liquisolid technique as a new approach to sustain propranolol hydrochloride release from tablet matrices. Int. J. Pharm., 2008, 362(1-2), 102-108.
[http://dx.doi.org/10.1016/j.ijpharm.2008.06.022] [PMID: 18647643]
[http://dx.doi.org/10.1016/j.ijpharm.2008.06.022] [PMID: 18647643]
[42]
Nokhodchi, A.; Aliakbar, R.; Desai, S.; Javadzadeh, Y. Liquisolid compacts: the effect of cosolvent and HPMC on theophylline release. Colloids Surf. B Biointerfaces, 2010, 79(1), 262-269.
[http://dx.doi.org/10.1016/j.colsurfb.2010.04.008] [PMID: 20451361]
[http://dx.doi.org/10.1016/j.colsurfb.2010.04.008] [PMID: 20451361]
[43]
Amit, C.; Upendra, N.; Neha, G.; Sharma, V.K.; Khosa, R.L. Enhancement of solubilization and bioavailability of poorly soluble drugs by physical and chemical modifications: a recent review. J. Adv. Pharm. Educ. Res., 2012, 2, 32-67.
[44]
Darwish, I.A.E.; El-Kamel, A.H. Dissolution enhancement of glibenclamide using Liquisolid tablet technology. Acta Pharm., 2001, 51, 173-181.
[45]
Djalal, T.; Hussin, M.H.; Hui Chuin, C.T.; Sabar, S. NurulFazita, M.R.; Taiwo, Owolabi F.A.; Hassan, T.M.; Haafiz, M.K. Microcrystalline cellulose: isolation, characterization and bio-composites application-A review. Int. J. Biol. Macromol., 2016, 93, 789-804.
[http://dx.doi.org/10.1016/j.ijbiomac.2016.09.056]
[http://dx.doi.org/10.1016/j.ijbiomac.2016.09.056]
[46]
Moreno, F.J.; Montilla, A.; Villamiel, M.; Corzo, N.; Olano, A. Analysis, structural characterization, and bioactivity of oligosaccharides derived from lactose. Electrophoresis, 2014, 35(11), 1519-1534.
[http://dx.doi.org/10.1002/elps.201300567] [PMID: 24446419]
[http://dx.doi.org/10.1002/elps.201300567] [PMID: 24446419]
[47]
Grote, S.; Kleinebudde, P. Roll Compaction/dry granulation of dibasic calcium phosphate anhydrous-does the morphology of the raw material influence the tablet ability of dry granules? J. Pharm. Sci., 2018, 107(4), 1104-1111.
[http://dx.doi.org/10.1016/j.xphs.2017.12.003] [PMID: 29247739]
[http://dx.doi.org/10.1016/j.xphs.2017.12.003] [PMID: 29247739]
[48]
Xu, G.; Shao, C.; Liao, X.; Tian, Y.; Chen, S. solution and characterization of polymorphic microsatellite loci from soiuy mullet. Conserv. Genet., 2009, 10, 653-655.
[http://dx.doi.org/10.1007/s10592-008-9602-5]
[http://dx.doi.org/10.1007/s10592-008-9602-5]
[49]
Kumari, A.; Sarkhel, G.; Choudhary, A. Preparation and characterization of polyvinylpyrollidone incorporated cellulose acetate membranes for ultra filtration of metal ion. J. Appl. Polym. Sci., 2014, 124, 300-308.
[http://dx.doi.org/10.1002/app.36616]
[http://dx.doi.org/10.1002/app.36616]
[50]
Suksaeree, J.; Monton, C.; Madaka, F.; Chusut, T.; Saingam, W.; Pichayakorn, W.; Boonme, P. Formulation, physicochemical characterization, and in vitro study of chitosan/HPMC blends-based herbal blended patches. AAPS PharmSciTech, 2015, 16(1), 171-181.
[http://dx.doi.org/10.1208/s12249-014-0216-6] [PMID: 25233803]
[http://dx.doi.org/10.1208/s12249-014-0216-6] [PMID: 25233803]
[51]
Viguié, J.; Molina-Boisseau, S.; Dufresne, A. Processing and characterization of waxy maize starch films plasticized by sorbitol and reinforced with starch nanocrystals. Macromol. Biosci., 2007, 7(11), 1206-1216.
[http://dx.doi.org/10.1002/mabi.200700136] [PMID: 17712803]
[http://dx.doi.org/10.1002/mabi.200700136] [PMID: 17712803]
[52]
Matulyte, I.; Marksa, M.; Ivanauskas, L.; Kalvėnienė, Z.; Lazauskas, R.; Bernatoniene, J. GC-MS analysis of the composition of the extracts and essential oil from Myristica fragrans seeds using magnesium aluminometasilicate as excipient. Molecules, 2019, 24(6), 1-12.
[http://dx.doi.org/10.3390/molecules24061062] [PMID: 30889896]
[http://dx.doi.org/10.3390/molecules24061062] [PMID: 30889896]
[53]
Chaulang, G.; Patel, P.; Hardikar, C.; Kelkar, M.; Bhosale, A.; Bhise, S. Formulation and evaluation of solid dispersions of furosemide in sodium starch glycolate. Trop. J. Pharm. Res., 2009, 8, 43-51.
[http://dx.doi.org/10.4314/tjpr.v8i1.14711]
[http://dx.doi.org/10.4314/tjpr.v8i1.14711]
[54]
Chang, S.Y.; Liu, L.; Asher, S.A. Preparation and properties of tailored morphology, monodisperse colloidal silica-cadmium sulfide nanocomposites. J. Am. Chem. Sa., 1994, 116, 6739-6744.
[http://dx.doi.org/10.1021/ja00094a032]
[http://dx.doi.org/10.1021/ja00094a032]
[55]
Abbaspour, M.R.; Sadeghi, F.; Garekani, H.A. Preparation and characterization of ibuprofen pellets based on Eudragit RS PO and RL PO or their combination. Int. J. Pharm., 2005, 303(1-2), 88-94.
[http://dx.doi.org/10.1016/j.ijpharm.2005.07.016] [PMID: 16153792]
[http://dx.doi.org/10.1016/j.ijpharm.2005.07.016] [PMID: 16153792]
[56]
Mukherjee, P.; Patra, C.R.; Ghosh, A.; Kumar, R.; Sastry, M. Characterization and catalytic activity of gold nanoparticles synthesized by auto reduction of aqueous chloroaurate ions with fumed silica. Chem. Mater., 2002, 14, 1678-1684.
[http://dx.doi.org/10.1021/cm010372m]
[http://dx.doi.org/10.1021/cm010372m]
[57]
Boltri, L.; Coceani, N.; De Curto, D.; Dobetti, L.; Esposito, P. Enhancement and modification of etoposide release from crospovidone particles loaded with oil-surfactant blends. Pharm. Dev. Technol., 1997, 2(4), 373-381.
[http://dx.doi.org/10.3109/10837459709022636] [PMID: 9552466]
[http://dx.doi.org/10.3109/10837459709022636] [PMID: 9552466]
[58]
Shah, U.; Augsburger, L. Multiple sources of sodium starch glycolate, NF: evaluation of functional equivalence and development of standard performance tests. Pharm. Dev. Technol., 2002, 7(3), 345-359.
[http://dx.doi.org/10.1081/PDT-120005731] [PMID: 12229266]
[http://dx.doi.org/10.1081/PDT-120005731] [PMID: 12229266]
[59]
Desai, P.M.; Liew, C.V.; Heng, P.W.S. Review of disintegrants and the disintegration phenomena. J. Pharm. Sci., 2016, 105(9), 2545-2555.
[http://dx.doi.org/10.1016/j.xphs.2015.12.019] [PMID: 27506604]
[http://dx.doi.org/10.1016/j.xphs.2015.12.019] [PMID: 27506604]
[60]
Plata, M.R.; Contento, A.M.; Ríos, A. Analytical characterization of PEG polymers by MEKC. Electrophoresis, 2010, 31(4), 679-687.
[http://dx.doi.org/10.1002/elps.200900617] [PMID: 20094992]
[http://dx.doi.org/10.1002/elps.200900617] [PMID: 20094992]
[61]
Quispe, C.A.; Coronado, C.J.; Carvalho, J.A. Glycerol: production, consumption, prices, characterization and new trends in combustion. Renew. Sustain. Energy Rev., 2013, 27, 475-493.
[http://dx.doi.org/10.1016/j.rser.2013.06.017]
[http://dx.doi.org/10.1016/j.rser.2013.06.017]
[62]
Harada, A.; Okada, M.; Li, J.; Kamachi, M. Preparation and characterization of inclusion complexes of poly(propy1ene glycol) with cyclodextrin. Macromolecule, 1995, 28, 8406-8411.
[http://dx.doi.org/10.1021/ma00128a060]
[http://dx.doi.org/10.1021/ma00128a060]
[63]
How, C.W.; Rasedee, A.; Abbasalipourkabir, R. Characterization and cytotoxicity of nanostructured lipid carriers formulated with olive oil, hydrogenated palm oil, and polysorbate 80. IEEE Trans. Nanobioscience, 2013, 12(2), 72-78.
[http://dx.doi.org/10.1109/TNB.2012.2232937] [PMID: 23268387]
[http://dx.doi.org/10.1109/TNB.2012.2232937] [PMID: 23268387]
[64]
Akbari, J.; Saeedi, M.; Semnani, K.M.; Kelidari, H.K. Moghanlou1, FS.; Zareh, G.; Rostamkalaei, S. The effect of tween 20, 60, and 80 on dissolution behavior of spironolactone in solid dispersions prepared by PEG 6000. Adv. Pharm. Bull., 2015, 5, 435-441.
[http://dx.doi.org/10.15171/apb.2015.059] [PMID: 26504767]
[http://dx.doi.org/10.15171/apb.2015.059] [PMID: 26504767]
[65]
Khazaeli, P.; Pardakhty, A.; Shoorabi, H. Caffeine-loaded niosomes: characterization and in vitro release studies. Drug Deliv., 2007, 14(7), 447-452.
[http://dx.doi.org/10.1080/10717540701603597] [PMID: 17994362]
[http://dx.doi.org/10.1080/10717540701603597] [PMID: 17994362]
[66]
Deshmukh, A.D.; Wasankar, S.R.; Burghate, R.M.; Ughade, M.A. Liquisolid technique for enhancing dissolution rate: a review. Res. J. Pharm. Dos. Forms Technol., 2013, 5, 1-6.
[67]
Komala, D.R.; Janga, K.Y.; Jukanti, R. Competence of raloxifene hydrochloride loaded liquisolid compacts for improved dissolution and intestinal permeation. J. Drug Deliv. Sci. Technol., 2015, 30, 232-241.
[http://dx.doi.org/10.1016/j.jddst.2015.10.020]
[http://dx.doi.org/10.1016/j.jddst.2015.10.020]
[68]
Adibkia, K.; Shokri, J.; Barzegar-Jalali, M.; Solduzian, M.; Javadzadeh, Y. Effect of solvent type on retardation properties of diltiazem HCl form liquisolid tablets. Colloids Surf. B Biointerfaces, 2014, 113, 10-14.
[http://dx.doi.org/10.1016/j.colsurfb.2013.08.017] [PMID: 24060925]
[http://dx.doi.org/10.1016/j.colsurfb.2013.08.017] [PMID: 24060925]
[69]
Enugula, P.; Sheik, N.; Izhar, A.S. Liquisolid technique based sustained release tablet of trimetazidine dihydrochloride, drug. Invent. Today., 2013, 5, 302-310.
[http://dx.doi.org/10.1016/j.dit.2013.08.006]
[http://dx.doi.org/10.1016/j.dit.2013.08.006]
[70]
Chella, N.; Narra, N.; Rama, R.T. Preparation and characterization of liquisolid compact foe improved dissolution of Telmisartan. Drug Deliv., 2014, 4, 1-10.
[71]
Badawy, M.A.; Kamel, A.O.; Sammour, O.A. Use of biorelevant media for assessment of a poorly soluble weakly basic drug in the form of liquisolid compacts: in vitro and in vivo study. Drug Deliv., 2016, 23(3), 818-827.
[http://dx.doi.org/10.3109/10717544.2014.917442] [PMID: 24892630]
[http://dx.doi.org/10.3109/10717544.2014.917442] [PMID: 24892630]
[72]
El-Hammadi, M.; Awad, N. Investigating the use of liquisolid compacts technique to minimize the influence of pH variations on loratadine release. AAPS PharmSciTech, 2012, 13(1), 53-58.
[http://dx.doi.org/10.1208/s12249-011-9719-6] [PMID: 22101967]
[http://dx.doi.org/10.1208/s12249-011-9719-6] [PMID: 22101967]
[73]
Khan, A.; Iqbal, Z.; Shah, Y.; Ahmad, L. Ismail; Ullah, Z.; Ullah, A. Enhancement of dissolution rate of class II drugs (Hydrochlorothiazide); a comparative study of the two novel approaches; solid dispersion and liqui-solid techniques. Saudi Pharm. J., 2015, 23(6), 650-657.
[http://dx.doi.org/10.1016/j.jsps.2015.01.025] [PMID: 26702260]
[http://dx.doi.org/10.1016/j.jsps.2015.01.025] [PMID: 26702260]
[74]
Hentzschel, C.M.; Sakmann, A.; Leopold, C.S. Suitability of various excipients as carrier and coating materials for liquisolid compacts. Drug Dev. Ind. Pharm., 2011, 37(10), 1200-1207.
[http://dx.doi.org/10.3109/03639045.2011.564184] [PMID: 21449826]
[http://dx.doi.org/10.3109/03639045.2011.564184] [PMID: 21449826]
[75]
Pezzini, B.R.; Beringhs, A.O.; Ferraz, H.G. Liquisolid technology applied to pellets: evaluation of the feasibility and dissolution performance using Felodipine as a model drug. Chem. Eng. Res. Des., 2016, 1, 1-8.
[http://dx.doi.org/10.1016/j.cherd.2016.01.037]
[http://dx.doi.org/10.1016/j.cherd.2016.01.037]
[76]
Khaled, K.A.; Asiri, Y.A.; El-Sayed, Y.M. In vivo evaluation of hydrochlorothiazide liquisolid tablets in beagle dogs. Int. J. Pharm., 2001, 222(1), 1-6.
[http://dx.doi.org/10.1016/S0378-5173(01)00633-0] [PMID: 11404027]
[http://dx.doi.org/10.1016/S0378-5173(01)00633-0] [PMID: 11404027]
[77]
Javadzadeh, Y.; Siahi Shadbad, M.R.; Barzegar-Jalali, M.; Nokhodchi, A. Dissolution rate of piroxicam using liquisolid compacts. II Farmco., 2005, 60, 361-365.
[78]
Ngiik, T.; Amal, A. Elkordy. Effects of Liquisolid formulations on dissolution of naproxen. Eur. J. Pharm. Biopharm., 2009, 23, 373-384.
[79]
Khames, A. Liquisolid technique: a promising alternative to conventional coating for improvement of photo-stability in solid dosage form. Drug. deli., 2013, 10, 1335-1343.
[80]
Yadav, P.S.; Kumar, V.; Singh, U.P.; Bhat, H.R.; Mazumder, B. Physicochemical characterization and in vitro dissolution studies of solid dispersions of ketoprofen with PVP K30 and d-mannitol. Saudi Pharm. J., 2013, 21(1), 77-84.
[http://dx.doi.org/10.1016/j.jsps.2011.12.007] [PMID: 24109206]
[http://dx.doi.org/10.1016/j.jsps.2011.12.007] [PMID: 24109206]
[81]
Vitta, G.V.; Deveswaran, R.; Bharath, S.; Basavaraj, B.; Madhavan, V. Formulation and characterization of ketoprofen liquisolid compacts by box-behnken design. Int. J. Pharm. Investig., 2012, 2, 150-33.
[82]
Hassan, M.A.; Suleiman, M.S.; Najib, N.M. Improvement of the in vitro dissolution characteristics of famotidine by inclusion in flcyclodextrin. Lnt. J. Pharma., 1990, 58, 19-24.
[http://dx.doi.org/10.1016/0378-5173(90)90282-9]
[http://dx.doi.org/10.1016/0378-5173(90)90282-9]
[83]
Redenti, E.; Peveri, T.; Zanol, M.; Ventura, P.; Gnappi, G.; Montenero, A. A study on the differentiation between amorphous piroxicam: fl-cyclodextrin complex and a mixture of the two amorphous components. Int. J. Pharm., 1996, 129, 289-294.
[http://dx.doi.org/10.1016/0378-5173(95)04357-8]
[http://dx.doi.org/10.1016/0378-5173(95)04357-8]
[84]
Javadzadeh, Y.; Siahi, M.R.; Asnaashari, S.; Nokhodchi, A. An investigation of physicochemical properties of piroxicam liquisolid compacts. Pharm. Dev. Technol., 2007, 12, 337-343.
[85]
Nijhawan, M.; Santhosh, A.; Babu, P.S.; Subrahmanyam, C.V.S. Solid state manipulation of Lornoxicam for co crystals – physicochemical characterization. Drug Dev. Ind. Pharm., 2013, 10, 1520-5762.
[PMID: 23829186]
[PMID: 23829186]
[86]
Srivastava, S.; Srivastava, D.; Nimisha, V.P. Liquisolid technique for enhancement of dissolution properties of lornoxicam, pharm. Biomed. Res., 2016, 2, 1-21.
[87]
Kaewnopparat, N.; Chuchom, T.; Sunthornpit, A.; Jangwang, A.; Kaewnopparat, S. Enhanced bromhexine hydrochloride solubility and dissolution by inclusion complexation with methylated β –cyclodextrin. Indian J. Pharm. Sci., 2009, 5, 114-122.
[88]
Jafari, E. Preparation, characterization and dissolution of solid dispersion of diclofenac sodium using eudragit E-100. J. Appl. Pharm. Sci., 2013, 3, 167-170.
[89]
Kulkarni, A.S.; Gaja, J.B. Formulation and evaluation of Liquisolid compact of diclofenac sodium. PDA J. Pharm. Sci. Technol., 2010, 64, 22-32.
[90]
Attia, D.A.R. In vitro and in vivo studies of repaglinide fast dissolving tablet utilizing solid dispersion techniques. Br. J. Pharm. Res., 2015, 5, 260-279.
[http://dx.doi.org/10.9734/BJPR/2015/14739]
[http://dx.doi.org/10.9734/BJPR/2015/14739]
[91]
Vogt, M.; Kunath, K.; Dressman, J.B. Dissolution enhancement of fenofibrate by micronization, cogrinding and spray-drying: comparison with commercial preparations. Eur. J. Pharm. Biopharm., 2008, 68(2), 283-288.
[http://dx.doi.org/10.1016/j.ejpb.2007.05.010] [PMID: 17574403]
[http://dx.doi.org/10.1016/j.ejpb.2007.05.010] [PMID: 17574403]
[92]
Karmarkar, A.B.; Gonjari, I.D.; Hosmani, A.H.; Dhabale, P.N.; Bhise, S.B. Dissolution rate enhancement of fenofibrate using liquisolid tablet technique. Lat. Am. J. Pharm., 2009, 28, 219-225.
[93]
Gohel, M.C.; Patel, L.D. Processing of nimesulide-PEG 400-PG-PVP solid dispersions: preparation, characterization, and in vitro dissolution. Drug Dev. Ind. Pharm., 2003, 29(3), 299-310.
[http://dx.doi.org/10.1081/DDC-120018203] [PMID: 12741611]
[http://dx.doi.org/10.1081/DDC-120018203] [PMID: 12741611]
[94]
Thadkala, K.; Voruganti, S.; Badari, S.R. Enhancement of dissolution rate of nimesulide by Liquisolid compaction technique. Int. J. Pharm. Tech. Res., 2012, 4, 1294-1302.
[95]
Rawat, S.; Jain, S.K. Rofecoxib-beta-cyclodextrin inclusion complex for solubility enhancement. Pharmazie, 2003, 58(9), 639-641.
[PMID: 14531460]
[PMID: 14531460]
[96]
Khalid, M. El-Say.; Ahmed, M.; Samy; Mohamed, I.; Fetouh. Formulation and evaluations of rofecoxib liquisolid tablets. Int. J. Pharm. Sci. Rev. Res., 2010, 3, 1-28.
[97]
Patel, M.; Tekade, A.; Gattani, S.; Surana, S. Solubility enhancement of lovastatin by modified locust bean gum using solid dispersion techniques. AAPS PharmSciTech, 2008, 9(4), 1262-1269.
[http://dx.doi.org/10.1208/s12249-008-9171-4] [PMID: 19115112]
[http://dx.doi.org/10.1208/s12249-008-9171-4] [PMID: 19115112]
[98]
Mokale, V.; Naik, J.; Wani, D.; Patil, J.; Yadav, S.; Verma, U. Preparation and in-vitro characterization of lovastatin liquisolid self-emulsified drug delivery system. Int. J. Chem. Env. Bio. Sci., 2014, 2, 2320-4087.
[99]
Wang, Z.; Sun, M.; Liu, T.; Gao, Z.; Ye, Q.; Tan, X.; Hou, Y.; Sun, J.; Wang, D.; He, Z. Co-amorphous solid dispersion systems of lacidipine-spironolactone with improved dissolution rate and enhanced physical stability. Asian J. Pharm. Sci., 2019, 14(1), 95-103.
[http://dx.doi.org/10.1016/j.ajps.2018.11.001] [PMID: 32104442]
[http://dx.doi.org/10.1016/j.ajps.2018.11.001] [PMID: 32104442]
[100]
Salmani, J.M.; Lv, H.; Asghar, S.; Zhou, J. Amorphous solid dispersion with increased gastric solubility in tandem with oral disintegrating tablets: a successful approach to improve the bioavailability of atorvastatin. Pharm. Dev. Technol., 2015, 20(4), 465-472.
[http://dx.doi.org/10.3109/10837450.2014.882938] [PMID: 24490758]
[http://dx.doi.org/10.3109/10837450.2014.882938] [PMID: 24490758]
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