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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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HIGHLIGHTS

A Brief Review on the Development of Novel Potentially Active Azetidin-2-ones Against Cancer

Author(s): Ligia S. da Silveira Pinto, Thatyana R. Alves Vasconcelos*, Claudia Regina B. Gomes and Marcus Vinícius N. de Souza

Volume 24, Issue 5, 2020

Page: [473 - 486] Pages: 14

DOI: 10.2174/1385272824666200303115444

Price: $65

Abstract

Azetidin-2-ones (β-lactams) and its derivatives are an important group of heterocyclic compounds that exhibit a wide range of pharmacological properties such as antibacterial, anticancer, anti-diabetic, anti-inflammatory and anticonvulsant. Efforts have been made over the years to develop novel congeners with superior biological activities and minimal potential for undesirable side effects. The present review aimed to highlight some recent discoveries (2013-2019) on the development of novel azetidin-2-one-based compounds as potential anticancer agents.

Keywords: Azetidin-2-ones, β-lactams, biological activity, cancer, drugs, heterocycles.

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Graphical Abstract

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