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Systematic Review Article

血清铁调素，铁调素铁蛋白比值与2型糖尿病风险:一项系统回顾和荟萃分析

卷 28, 期 6, 2021

发表于: 07 February, 2020

页: [1224 - 1233] 页: 10

弟呕挨: 10.2174/0929867327666200207120158

价格: $65

摘要

目的：对2型糖尿病与血清铁调素和铁调素/铁蛋白比值的关系进行meta分析。 方法：使用所有相关关键词搜索以下数据库:Web of Science、Medline、Scopus、Embase和谷歌Scholar。所有检查2型糖尿病与血清铁调素或铁调素/铁蛋白比值关系的研究均纳入本meta分析和提供的系统综述，均于2011年至2018年以英文发表。使用随机效应模型来汇集标准化平均差(SMD)。 结果：8项研究比较了2型糖尿病患者和健康对照者血清铁调素的SMD (n例=878;n = 2306)控制。血清铁调素的合并SMD在研究组之间没有显著差异(SMD: 0.04;95%可信区间(CI): -0.29 - 0.35)。相比之下，五项研究检查了血清铁调素/铁蛋白比值(n例=229;对照组=1426)，与2型糖尿病的风险呈负相关(SMD: -0.52;95%可信区间(CI): -0.85 ~ -0.19)。血清铁调素(Egger’s test: P =0.97)或hepcidin/铁蛋白比值(Egger’s test: P =0.75)与2型糖尿病之间没有发表偏倚。 结论：

关键词: 2型糖尿病，铁调素，铁蛋白，风险标志物，meta分析，血清铁调素

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