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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

乳腺癌相关的肺转移中癌细胞衍生的分泌因子：其机制和未来前景。

卷 20, 期 3, 2020

页: [168 - 186] 页: 19

弟呕挨: 10.2174/1568009620666191220151856

价格: $65

摘要

在乳腺癌中，肺是仅次于骨骼的第二个最常见的转移部位。多种因素可导致继发于乳腺癌的肺转移。癌细胞衍生的分泌因子通常称为“癌症分泌素”。它们在乳腺癌肺转移的机制中显示出迅速的作用。它们也是与宿主相关的肿瘤微环境的主要成分。通过癌细胞与细胞外基质成分之间的串扰，透明质酸，胶原蛋白，层粘连蛋白和纤连蛋白等癌细胞衍生的细胞外基质成分（CCEC）在癌症的主要部位（乳房）引起ECM重塑。但是，在次要部位（肺），腱生蛋白C，骨膜素和赖氨酰氧化酶，与转移前分子Coco和GALNT14一起，通过促进ECM重塑和肺转移细胞定植，促进了转移前的生态位（PMN）的形成。癌细胞衍生的分泌因子通过诱导癌细胞在原发部位的增殖，其通过组织和血管的侵袭以及PMN中转移细胞的早期定植来增强乳腺癌的肺转移机制。根据生化结构，这些分泌因子大致分为蛋白质和非蛋白质。这是首次强调癌细胞来源的分泌因子在乳腺癌肺转移（BCLM）中的作用的综述。它还列举了迄今为止在乳腺癌细胞系和动物模型中进行的各种研究，这些研究描述了各种类型的源自癌细胞的分泌因子在乳腺癌肺转移过程中的迅速作用。将来，通过治疗性靶向这些癌症驱动分子，可以成功治疗乳腺癌中这种特定类型的器官向性转移。

关键词: 乳腺癌肺转移，分泌因子，转移前的生态位，肿瘤微环境，细胞系和动物模型。

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