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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Review Article

从海洋生物资源中分离出抗阿尔茨海默氏病的材料：综述

卷 16, 期 10, 2019

页: [895 - 906] 页: 12

弟呕挨: 10.2174/1567205016666191024144044

价格: $65

摘要

在老年人口中发现的最常见的痴呆类型是阿尔茨海默氏病。该病不仅影响患者及其家人，而且影响整个社会，因此，研究人员的主要重点是寻找治疗AD的新生物活性材料。海洋环境是功能成分的丰富来源，迄今为止，我们可以找到与从海洋环境中分离出的抗阿尔茨海默氏病化合物有关的充分研究。因此，本综述着重于海洋生物资源中的抗阿尔茨海默氏病物质，然后阐述了海洋海藻，海洋动物和海洋微生物中的抗阿尔茨海默氏病化合物。此外，由于疾病的复杂性，已经阐明了不同的假设，并且已经分离出活性化合物以抑制病理生理机制的不同阶段。本综述总结了海洋动物的硫酸化多糖，糖蛋白和海洋藻类的酶水解产物，海洋动物的肽，饮食中的omega-3多不饱和脂肪酸和骨骼多糖以及海洋微生物的次生代谢产物，这些物质是来自海洋的抗阿尔茨海默氏病化合物。

关键词: 阿尔茨海默氏病，淀粉样β蛋白，tau蛋白，海藻，神经退行性变，生物活性化合物，痴呆。

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