Chromosome 17 in Fronto Temporal Lobak Degeneration (FTLD): From MAPT to Progranulin and Back

Title: Chromosome 17 in Fronto Temporal Lobak Degeneration (FTLD): From MAPT to Progranulin and Back

Volume: 8 Issue: 3

Author(s): A. Alberici, M. Cosseddu, A. Padovani and B. Borroni

Affiliation:

Keywords: Fronto temporal lobak degeneration, MAPT, progranulin, DLDH, PNFA, CBS, PSP, frontal atrophy, FTLD-MND, CHMP2B, language dysfunction, (TAR)-DNA-binding, NCI, ALS

Abstract: Frontotemporal Lobar degeneration (FTLD) is one of the most important neurodegenerative conditions, affecting in the presenium, but more recently recognized also in aged population. The strong genetic background, along with autopsy determinations prompted the identification of the two major genes associated to the disease: MAPT gene, and Progranulin (PGRN) gene. In this review, we highlighted the milestones of these discoveries, and their implication for the development of future therapeuthical approaches.

Cite this article as:

Alberici A., Cosseddu M., Padovani A. and Borroni B., Chromosome 17 in Fronto Temporal Lobak Degeneration (FTLD): From MAPT to Progranulin and Back, Current Alzheimer Research 2011; 8 (3) . https://dx.doi.org/10.2174/156720511795563737