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Current Organic Synthesis

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ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

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Structure-Bioactivity Relationship Study of Xanthene Derivatives: A Brief Review

Author(s): Aref G. Ghahsare, Zahra S. Nazifi* and Seyed M.R. Nazifi*

Volume 16, Issue 8, 2019

Page: [1071 - 1077] Pages: 7

DOI: 10.2174/1570179416666191017094908

Price: $65

Abstract

Over the last decades, several heterocyclic derivatives compounds have been synthesized or extracted from natural resources and have been tested for their pharmaceutical activities. Xanthene is one of these heterocyclic derivatives. These compounds consist of an oxygen-containing central heterocyclic structure with two more cyclic structures fused to the central cyclic compound. It has been shown that xanthane derivatives are bioactive compounds with diverse activities such as anti-bacterial, anti-fungal, anti-cancer, and anti-inflammatory as well as therapeutic effects on diabetes and Alzheimer. The anti-cancer activity of such compounds has been one of the main research fields in pharmaceutical chemistry. Due to this diverse biological activity, xanthene core derivatives are still an attractive research field for both academia and industry. This review addresses the current finding on the biological activities of xanthene derivatives and discussed in detail some aspects of their structure-activity relationship (SAR).

Keywords: Xanthene, structure-activity relationship (SAR), biological activity, polycyclic, natural resources, pharmaceutical activities.

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