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Review Article

乳腺癌中的铜浓度:一项系统综述和荟萃分析

卷 27, 期 37, 2020

页: [6373 - 6383] 页: 11

弟呕挨: 10.2174/0929867326666190918120209

价格: $65

摘要

乳腺癌是最常见的肿瘤，占全世界女性癌症总数的16%。对不同身体样本中铜浓度的研究表明，铜含量与乳腺癌风险之间存在关联。本系统综述和荟萃分析总结了已发表的研究结果，并检验了这种关联。我们搜索PubMed、Scopus、Web of Science、谷歌Scholar数据库以及相关出版物的参考列表。通过计算癌症病例和对照组Cu水平之间的标准化平均差异(SMDs)和相应的置信区间(CIs)，以及I2统计量，来检验异质性。在原始研究中使用的样本之后，铜的浓度在三个亚组中进行检测:血清或血浆、乳腺组织和头皮毛发。我们确定了1984年至2017年发表的1711项相关研究。在任何研究样本中检测的乳腺癌病例和铜含量对照之间没有统计学上的显著差异;SMD (95% CI)为-0.01 (-1.06 - 1.03;P = 0.98)，血液或血清为0.51 (-0.70 - 1.73;P = 0.41)乳腺组织，-0.88 (-3.42 - 1.65;P = 0.50)。然而，所有亚组研究之间的异质性都非常高(P < 0.001)。我们没有发现发表偏倚的证据(P = 0.91)。这项荟萃分析的结果并不支持铜含量与乳腺癌之间的联系。然而，由于原始研究的结果异质性较高，这一结论需要经过精心设计的前瞻性研究来证实。

关键词: 铜，乳腺癌，妇女，血液，乳腺组织，头发分析

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