Search Result "4-hydroxy-tolbutamide"


An In Vitro, High Throughput, Seven CYP Cocktail Inhibition Assay for the Evaluation of New Chemical Entities Using LC-MS/MS

Journal: Drug Metabolism Letters
Volume: 5 Issue: 1 Year: 2011 Page: 17-24
Author(s): Jennifer N. Otten, Gary P. Hingorani, Dylan P. Hartley, Scott D. Kragerud, Ronald B. Franklin

Research Article

Reducing Hepatotoxicity Mechanism of Radix Wikstroemia Indica byProcessing with “Sweat Soaking Method” Using UPLC-MS/MS and aCocktail Probe Substrate

Journal: Letters in Drug Design & Discovery
Volume: 20 Issue: 7 Year: 2023 Page: 965-976
Author(s):

A Novel Plated Hepatocyte Relay Assay (PHRA) for In Vitro Evaluation of Hepatic Metabolic Clearance of Slowly Metabolized Compounds

Journal: Drug Metabolism Letters
Volume: 10 Issue: 1 Year: 2016 Page: 3-15
Author(s): Chi-Chi Peng,Utkarsh Doshi,Chandra Prakash,Albert P. Li

Review Article

In vivo Phenotyping Methods: Cytochrome P450 Probes with Emphasis on the Cocktail Approach

Journal: Current Pharmaceutical Design
Volume: 23 Issue: 14 Year: 2017 Page: 2035-2049
Author(s): Guillermo Alberto Keller,María Laura Ferreirós Gago,Roberto Alejandro Diez,Guillermo Di Girolamo

Review Article

Use of Cocktail Probe Drugs for Indexing Cytochrome P450 Enzymes in Clinical Pharmacology Studies – Review of Case Studies

Journal: Drug Metabolism Letters
Volume: 13 Issue: 1 Year: 2019 Page: 3-18
Author(s): Poonam Giri,Harilal Patel,Nuggehally R. Srinivas

A Non-acidic Sulfaphenazole Analog Demonstrating High Intrinsic Clearance and Selectivity by Canine CYP2C21

Journal: Drug Metabolism Letters
Volume: 5 Issue: 4 Year: 2011 Page: 253-258
Author(s): Charles W. Locuson, Josh F. Alfaro, Matthew J. Zaya, Denis Billen, Julie A. White, Jeffrey P. Jones

Research Article

Synthesis and Investigating Hypoglycemic and Hypolipidemic Activities of Some Glibenclamide Analogues in Rats

Journal: Mini-Reviews in Medicinal Chemistry
Volume: 14 Issue: 2 Year: 2014 Page: 208-213
Author(s): Abbas Ahmadi, Mohsen Khalili, Khadijeh Khatami, Majid Farsadrooh, Babak Nahri-Niknafs

De-Risking Bio-therapeutics for Possible Drug Interactions Using Cryopreserved Human Hepatocytes

Journal: Current Drug Metabolism
Volume: 13 Issue: 7 Year: 2012 Page: 923-929
Author(s): Shannon Dallas,Carlo Sensenhauser,Ameesha Batheja,Monica Singer,Maria Markowska,Cindy Zakszewski,Rao N.V.S. Mamidi,Michael McMillia,Chao Han,Honghui Zhou,Jose Silva

Investigations Towards New Antidiabetic Drugs from Fungal Endophytes Associated with Salvadora Oleoides Decne

Journal: Medicinal Chemistry
Volume: 9 Issue: 4 Year: 2013 Page: 624-632
Author(s): Seema Dhankhar, Sandeep Dhankhar, Jaya Parkash Yadav

Review Article open access plus

Xanthine Oxidoreductase in Drug Metabolism: Beyond a Role as a Detoxifying Enzyme

Journal: Current Medicinal Chemistry
Volume: 23 Issue: 3 Year: 2016 Page: 4027-4036
Author(s): Maria Giulia Battelli, Letizia Polito, Massimo Bortolotti, Andrea Bolognesi

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