Abstract
Emerging data suggest that primary dysfunction in the tumor microenvironment is crucial for carcinogenesis. These recent findings make a compelling case for targeting the milieu for cancer chemoprevention as well as therapy. The stroma is an integral part of its physiology, and functionally, one cannot totally dissociate the tumor surrounding from the tumor cells. A thorough understanding of the tumor and stroma will aid us in developing new treatment targets. In this review, we shed light at the key aspects of the carcinogenic process and how oxidative stress and inflammation contribute to this process. We dissect the connection between metastasis and oxidative stress and focus on the key players in the tumor microenvironment that leads to inflammation, oxidative stress and DNA damage. Moreover, we consider the role of inflammation in disease, specifically cancer and metastasis. Finally, we discuss the potential applications in prognosis and cancer treatment.
Keywords: Carcinogenesis, DNA damage, genomic instability, inflammation, oxidative stress, tumor microenvironment, homeostasis, tumorigenesis, cell proliferation, apoptosis, neoplasia, malignant phenotype, mutagenesis, metastasis, DNA mutations
Current Molecular Medicine
Title:The Interplay Between Inflammation and Oxidative Stress in Carcinogenesis
Volume: 12 Issue: 6
Author(s): S. Nowsheen, K. Aziz, T. B. Kryston, N. F. Ferguson and A. Georgakilas
Affiliation:
Keywords: Carcinogenesis, DNA damage, genomic instability, inflammation, oxidative stress, tumor microenvironment, homeostasis, tumorigenesis, cell proliferation, apoptosis, neoplasia, malignant phenotype, mutagenesis, metastasis, DNA mutations
Abstract: Emerging data suggest that primary dysfunction in the tumor microenvironment is crucial for carcinogenesis. These recent findings make a compelling case for targeting the milieu for cancer chemoprevention as well as therapy. The stroma is an integral part of its physiology, and functionally, one cannot totally dissociate the tumor surrounding from the tumor cells. A thorough understanding of the tumor and stroma will aid us in developing new treatment targets. In this review, we shed light at the key aspects of the carcinogenic process and how oxidative stress and inflammation contribute to this process. We dissect the connection between metastasis and oxidative stress and focus on the key players in the tumor microenvironment that leads to inflammation, oxidative stress and DNA damage. Moreover, we consider the role of inflammation in disease, specifically cancer and metastasis. Finally, we discuss the potential applications in prognosis and cancer treatment.
Export Options
About this article
Cite this article as:
Nowsheen S., Aziz K., B. Kryston T., F. Ferguson N. and Georgakilas A., The Interplay Between Inflammation and Oxidative Stress in Carcinogenesis, Current Molecular Medicine 2012; 12 (6) . https://dx.doi.org/10.2174/156652412800792642
DOI https://dx.doi.org/10.2174/156652412800792642 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Fetal Mesenchymal Stem Cells in Cancer Therapy
Current Stem Cell Research & Therapy Strategies for the Biological Evaluation of Gold Anticancer Agents
Anti-Cancer Agents in Medicinal Chemistry Recent Advances in Small-Molecule HIV-1 Integrase Inhibitors
Current Medicinal Chemistry Development of Novel Therapeutic Drugs in Humans from Plant Antimicrobial Peptides
Current Protein & Peptide Science On the Origin of Epidermal Cancers
Current Molecular Medicine BCR-ABL Inhibitors in Chronic Myeloid Leukemia: Process Chemistry and Biochemical Profile
Current Medicinal Chemistry Development of New Drugs that Act Through Membrane Receptors and Involve an Action of Inverse Agonism
Recent Patents on CNS Drug Discovery (Discontinued) Radionuclide Based Imaging of Prostate Cancer
Current Topics in Medicinal Chemistry Notch Signalling: A Potential Therapeutic Pathway in Oral Squamous Cell Carcinoma
Endocrine, Metabolic & Immune Disorders - Drug Targets <i>Click</i> Reaction in the Synthesis of Dendrimer Drug-delivery Systems
Current Medicinal Chemistry Angiogenesis Inhibitors: Current & Future Directions
Current Pharmaceutical Design Advances in the Chemistry and Pharmacology of Ecteinascidins, A Promising New Class of Anticancer Agents
Current Medicinal Chemistry - Anti-Cancer Agents Nutritional and Therapeutic Potential of Garlic and Onion (Allium sp.)
Current Nutrition & Food Science Cell to Cell Spreading of Misfolded Proteins as a Therapeutic Target in Motor Neuron Disease
Current Medicinal Chemistry Melphalan in Regional Chemotherapy for Locally Recurrent Metastatic Melanoma
Current Topics in Medicinal Chemistry DNA Repair in Premature Aging Disorders and Neurodegeneration
Current Aging Science Patent Selections:
Recent Patents on Anti-Cancer Drug Discovery The PKB/AKT Pathway in Cancer
Current Pharmaceutical Design Liposomes: An Emerging Approach for the Treatment of Cancer
Current Pharmaceutical Design Alkylphospholipids are Signal Transduction Modulators with Potential for Anticancer Therapy
Anti-Cancer Agents in Medicinal Chemistry