Abstract
A quantitative structure- activity relationship (QSAR) study has been made on a series of thiophene derivatives acting as anti-HCV agents. Significant correlations are found between anti-HCV potencies and some physicochemical parameters. The study reveals that the activity can be controlled by molecular connectivity, Hammett constant, and some indicator variables. Using the correlations obtained, some new prospective compounds having high potency have been predicted.
Keywords: Anti-hepatitis C virus (HCV) agents, Hepatitis C virus inhibitors, QSAR study, Thiophenes
Letters in Drug Design & Discovery
Title:A QSAR Study on Some Thiophene Derivatives Acting as Anti-HCV Agents
Volume: 9 Issue: 4
Author(s): Jonish Varshney, Anjana Sharma, Satya P. Gupta
Affiliation:
Keywords: Anti-hepatitis C virus (HCV) agents, Hepatitis C virus inhibitors, QSAR study, Thiophenes
Abstract: A quantitative structure- activity relationship (QSAR) study has been made on a series of thiophene derivatives acting as anti-HCV agents. Significant correlations are found between anti-HCV potencies and some physicochemical parameters. The study reveals that the activity can be controlled by molecular connectivity, Hammett constant, and some indicator variables. Using the correlations obtained, some new prospective compounds having high potency have been predicted.
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Cite this article as:
Jonish Varshney, Anjana Sharma, Satya P. Gupta , A QSAR Study on Some Thiophene Derivatives Acting as Anti-HCV Agents, Letters in Drug Design & Discovery 2012; 9 (4) . https://dx.doi.org/10.2174/157018012799859945
DOI https://dx.doi.org/10.2174/157018012799859945 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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