Abstract
Hydrogels are currently applied in the treatment of numerous degenerative diseases because of their three dimensional (3D) nature, high water content and wide range of polymers that can be used for their fabrication. Hydrogels have been investigated and commercialized, for example, as soft contact lens-based ophthalmic drug delivery systems. These novel devices improved the bioavailability of ophthalmic drugs and their residence time. Hydrogels are also being investigated to facilitate and augment targeted delivery of chemotherapeutic agents. This approach minimizes significantly the side effects associated with conventional administration of anti-cancer therapeutics. The application of hydrogels as 3D scaffold has recently gained momentum because they can mimic key features of the extracellular matrix. For this reason, hydrogels are representing a viable alternative to traditional tumor xenograft in cancer biology studies. This review highlights recent advances in the development of hydrogels that are applied in degenerative diseases such as ocular, cancer, spine and cartilage degenerative pathologies.
Keywords: Hydrogel, stimuli-responsive, drug delivery systems, degenerative diseases, embolics, 3D scaffolds, high water content, polymers, ophthalmic drugs, residence time
Current Pharmaceutical Design
Title:Advances in Hydrogels Applied to Degenerative Diseases
Volume: 18 Issue: 18
Author(s): Damia Mawad, Elizabeth Anne Boughton, Philip Boughton and Antonio Lauto
Affiliation:
Keywords: Hydrogel, stimuli-responsive, drug delivery systems, degenerative diseases, embolics, 3D scaffolds, high water content, polymers, ophthalmic drugs, residence time
Abstract: Hydrogels are currently applied in the treatment of numerous degenerative diseases because of their three dimensional (3D) nature, high water content and wide range of polymers that can be used for their fabrication. Hydrogels have been investigated and commercialized, for example, as soft contact lens-based ophthalmic drug delivery systems. These novel devices improved the bioavailability of ophthalmic drugs and their residence time. Hydrogels are also being investigated to facilitate and augment targeted delivery of chemotherapeutic agents. This approach minimizes significantly the side effects associated with conventional administration of anti-cancer therapeutics. The application of hydrogels as 3D scaffold has recently gained momentum because they can mimic key features of the extracellular matrix. For this reason, hydrogels are representing a viable alternative to traditional tumor xenograft in cancer biology studies. This review highlights recent advances in the development of hydrogels that are applied in degenerative diseases such as ocular, cancer, spine and cartilage degenerative pathologies.
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Cite this article as:
Mawad Damia, Anne Boughton Elizabeth, Boughton Philip and Lauto Antonio, Advances in Hydrogels Applied to Degenerative Diseases, Current Pharmaceutical Design 2012; 18 (18) . https://dx.doi.org/10.2174/138161212800492895
DOI https://dx.doi.org/10.2174/138161212800492895 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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