Abstract
Evidence for the medicinal and health benefits of polyphenols in green tea for the prevention of chronic diseases such as heart disease, various types of cancer and neurodegenerative diseases is advancing. Their in vivo effectiveness and molecular mechanisms are difficult to elucidate and remain a challenging task. We review the redox responsiveness and amyloid protein perturbation biophysical properties of the major green tea polyphenol constituent (-)- epigallocatechin-3-gallate [EGCG].
Keywords: EGCG, green tea antioxidants, prooxidants, anti-cancer, neuroprotection, Alzheimer’s disease
Mini-Reviews in Medicinal Chemistry
Title:Redox Chemistry of Green Tea Polyphenols: Therapeutic Benefits in Neurodegenerative Diseases
Volume: 12 Issue: 5
Author(s): H. M. Hugel and N. Jackson
Affiliation:
Keywords: EGCG, green tea antioxidants, prooxidants, anti-cancer, neuroprotection, Alzheimer’s disease
Abstract: Evidence for the medicinal and health benefits of polyphenols in green tea for the prevention of chronic diseases such as heart disease, various types of cancer and neurodegenerative diseases is advancing. Their in vivo effectiveness and molecular mechanisms are difficult to elucidate and remain a challenging task. We review the redox responsiveness and amyloid protein perturbation biophysical properties of the major green tea polyphenol constituent (-)- epigallocatechin-3-gallate [EGCG].
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Cite this article as:
M. Hugel H. and Jackson N., Redox Chemistry of Green Tea Polyphenols: Therapeutic Benefits in Neurodegenerative Diseases, Mini-Reviews in Medicinal Chemistry 2012; 12 (5) . https://dx.doi.org/10.2174/138955712800493906
DOI https://dx.doi.org/10.2174/138955712800493906 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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