Abstract
In this review article are introduced some current topics concerning drug nanocrystals related to their physicochemical properties and production technologies with reference to patents. The physicochemical properties of nanonized drugs (i.e. drug nanocrystals) are individual, unique, and different from those of micronized drugs. As a result, drug nanocrystals have some superior pharmaceutical properties compared with their micronized equivalents (e.g. improved solubility and bioavailability). Already some drug nanocrystal products are commercially available. Drug nanocrystallization is an innovative formulation principle mainly for poorly soluble drugs. The special features of drug nanocrystals and their production technologies are described.
Keywords: Bottom-up technology, cancer therapy, combination technology, Drug nanocrystals, homogenization technique, laser ablation technique, milling technique, nanomedicine, nanoparticles, nano spray dryer, ophthalmology, photodynamic therapy, precipitation technique, spray dryer technique, top-down technology, nanonized drugs, micronized drugs, bioavailability, soluble drugs
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