Abstract
Staphylococcus aureus, one of the major pathogenic bacteria, is associated with substantial morbidity and mortality. The disease burden of staphylococcal infections is significant, which is primarily attributed to its adaptability and resistance to environmental stresses. S. aureus has the ability to develop multiple resistances to antimicrobial agents. These high resistances make pathogenicity of S. aureus one of the most complex mechanisms to understand and manage. Proteomic and bioinformatics approaches show great potential in exploring microbial adaptation strategies, ability to cause disease by pathogenic bacteria and the development of diagnostic tools. A summary of the latest developments in the application of ‘omics’ technologies to understand resistance mechanisms in S. aureus and their future role in antistaphylococcal vaccine and/or drug discovery is given here.
Keywords: Bioinformatics, methicillin-resistant, pathogenicity, proteomics, Staphylococcus aureus, virulence, microbiological sciences, post-genomic, polyacrylamide gel, electrophoresis, metabolism, stress/starvation
Current Proteomics
Title: Proteomic and Bioinformatics Tools to Understand Virulence Mechanisms in Staphylococcus aureus
Volume: 9 Issue: 1
Author(s): Malik Altaf Hussain and Flavia Huygens
Affiliation:
Keywords: Bioinformatics, methicillin-resistant, pathogenicity, proteomics, Staphylococcus aureus, virulence, microbiological sciences, post-genomic, polyacrylamide gel, electrophoresis, metabolism, stress/starvation
Abstract: Staphylococcus aureus, one of the major pathogenic bacteria, is associated with substantial morbidity and mortality. The disease burden of staphylococcal infections is significant, which is primarily attributed to its adaptability and resistance to environmental stresses. S. aureus has the ability to develop multiple resistances to antimicrobial agents. These high resistances make pathogenicity of S. aureus one of the most complex mechanisms to understand and manage. Proteomic and bioinformatics approaches show great potential in exploring microbial adaptation strategies, ability to cause disease by pathogenic bacteria and the development of diagnostic tools. A summary of the latest developments in the application of ‘omics’ technologies to understand resistance mechanisms in S. aureus and their future role in antistaphylococcal vaccine and/or drug discovery is given here.
Export Options
About this article
Cite this article as:
Altaf Hussain Malik and Huygens Flavia, Proteomic and Bioinformatics Tools to Understand Virulence Mechanisms in Staphylococcus aureus, Current Proteomics 2012; 9 (1) . https://dx.doi.org/10.2174/157016412799746245
DOI https://dx.doi.org/10.2174/157016412799746245 |
Print ISSN 1570-1646 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6247 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Oral Cavity, Biofilms and Ventilator-Associated Pneumonia
Current Respiratory Medicine Reviews The Role of the Coagulase-negative Staphylococci (CoNS) in Infective Endocarditis; A Narrative Review from 2000 to 2020
Current Pharmaceutical Biotechnology Novel Strategies for Combating Pathogenic Biofilms Using Plant Products and Microbial Antibiosis
Current Pharmaceutical Biotechnology Bacterial Adaptation and Infection
Inflammation & Allergy - Drug Targets (Discontinued) Polyproline and Triple Helix Motifs in Host-Pathogen Recognition
Current Protein & Peptide Science Oral Factor Xa (FXa) Inhibitors for Treatment of Heparin-induced Thrombocytopenia (HIT)
Current Drug Therapy Therapeutic Modulation of Cytokines in Chronic Infectious Diseases
Current Pharmaceutical Design Older Adults Prescribed Methadone: A Review of the Literature Across the Life Span from Opiate Initiation to Methadone Maintenance Treatment
Current Drug Abuse Reviews Use of Nanoparticles as Therapy for Methicillin-Resistant Staphylococcus aureus Infections
Current Drug Metabolism Update on Childhood Brucellosis
Recent Patents on Anti-Infective Drug Discovery Therapeutic Utilities of Pediatric Cardiac Catheterization
Current Cardiology Reviews The Importance of Guidelines in the Development and Application of Probiotics
Current Pharmaceutical Design Prediction of Degeneration of Native and Bioprosthetic Aortic Valves:Issue-Related Particularities of Diabetes Mellitus
Infectious Disorders - Drug Targets Heart Failure in South America
Current Cardiology Reviews Etiology of Neuroinflammatory Pathologies in Neurodegenerative Diseases: A Treatise
Current Psychopharmacology Coarctation of the Aorta - An Evolution of Therapeutic Options
Current Cardiology Reviews Bacteriophage and Peptidoglycan Degrading Enzymes with Antimicrobial Applications
Recent Patents on Biotechnology Annexin A5 Imaging: An Academic Research – Clinical Trials and Theses
Current Molecular Imaging (Discontinued) Methylene Blue and Vasoplegia: Who, When, and How?
Mini-Reviews in Medicinal Chemistry Differential Binding of L- vs. D-isomers of Cationic Antimicrobial Peptides to the Biofilm Exopolysaccharide Alginate
Protein & Peptide Letters