Abstract
Gene therapy concept has been being overcome massive challenges from 1972 in ethical, socio-economical and developmental issues. In this review, we have attempted to go through almost all the arenas and described in a methodical way that reflects not only the initial ethical and scientific thoughts but also adorned a solid depiction of gene therapy related physico-chemical barriers, approaches and strategies till to date.
Keywords: Nanoparticles, plasmid DNA, transfection, targeting, vectors, vaccines, GENE DELIVERY, PLASMID BASED GENE EXPRESSION, Recombinant Adenovirus vector, Recombinant Retrovirus Vector, Recombinant Herpes Simplex Virus Vector, VIRUS INDEPENDENT GENE DELIVERY, HYBRID VECTORS, X-SCID
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