Abstract
Recent evidence has associated the aberrant, proximal re-expression of various cell cycle control elements with neuronal cell vulnerability in Alzheimers and Parkinsons diseases, as a common chronic neurodegeneration. This phenomenon associated with oncogenic transduction pathways activation has attracted the interest of scientists all over the world for a few years now. The purpose of this paper is to outline areas of research related to oncogenic factors or medicines in the context of potential applications for future treatment of the above mentioned chronic and, largely, incurable diseases.
Keywords: Alzheimer's disease, Parkinson's disease, oncogenes, cell cycle, mitochondria
CNS & Neurological Disorders - Drug Targets
Title: Implication of Oncogenic Signaling Pathways as a Treatment Strategy for Neurodegenerative Disorders – Contemporary Approaches
Volume: 10 Issue: 2
Author(s): Adrian Sieradzki, Bharat B. Yendluri, Hector H. Palacios, Kalpana Parvathaneni, V. Prakash Reddy, Mark E. Obrenovich, Kazimierz Gasiorowski, Jerzy Leszek and Gjumrakch Aliev
Affiliation:
Keywords: Alzheimer's disease, Parkinson's disease, oncogenes, cell cycle, mitochondria
Abstract: Recent evidence has associated the aberrant, proximal re-expression of various cell cycle control elements with neuronal cell vulnerability in Alzheimers and Parkinsons diseases, as a common chronic neurodegeneration. This phenomenon associated with oncogenic transduction pathways activation has attracted the interest of scientists all over the world for a few years now. The purpose of this paper is to outline areas of research related to oncogenic factors or medicines in the context of potential applications for future treatment of the above mentioned chronic and, largely, incurable diseases.
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Sieradzki Adrian, B. Yendluri Bharat, H. Palacios Hector, Parvathaneni Kalpana, Prakash Reddy V., E. Obrenovich Mark, Gasiorowski Kazimierz, Leszek Jerzy and Aliev Gjumrakch, Implication of Oncogenic Signaling Pathways as a Treatment Strategy for Neurodegenerative Disorders – Contemporary Approaches, CNS & Neurological Disorders - Drug Targets 2011; 10 (2) . https://dx.doi.org/10.2174/187152711794480410
DOI https://dx.doi.org/10.2174/187152711794480410 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
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