Differentiation of CD8 T Cells in Response to Acute and Chronic Viral Infections: Implications for HIV Vaccine Development

Title: Differentiation of CD8 T Cells in Response to Acute and Chronic Viral Infections: Implications for HIV Vaccine Development

Volume: 5 Issue: 2

Author(s): J. D. Miller, D. Masopust, E. J. Wherry, S. Kaech, G. Silvestri and R. Ahmed

Affiliation:

Keywords: cd t cells, lcmv, hiv vaccine, differentiation, immune memory

Abstract: Successful HIV vaccine strategies will likely require the induction of robust cellular immune responses, in addition to strong humoral responses. Unfortunately, there is no clear molecular definition of an effective HIV-specific CD8 T cell response. In this review, we discuss the differentiation of CD8 T cells in response to acute and chronic viral infections. We then apply concepts derived from these studies to predict the desirable characteristics of HIV-specific CD8 T cell memory.

Cite this article as:

Miller D. J., Masopust D., Wherry J. E., Kaech S., Silvestri G. and Ahmed R., Differentiation of CD8 T Cells in Response to Acute and Chronic Viral Infections: Implications for HIV Vaccine Development, Current Drug Targets - Infectious Disorders 2005; 5 (2) . https://dx.doi.org/10.2174/1568005054201544

DOI https://dx.doi.org/10.2174/1568005054201544	Print ISSN 1568-0053
Publisher Name Bentham Science Publisher	Online ISSN 1875-5852