Abstract
Today, plasmid DNA is becoming increasingly important as the next generation of biotechnology products (gene medicines and DNA vaccines) make their way into clinical trials, and eventually into the pharmaceutical marketplace. This review summarizes recent patents and patent applications relating to plasmid manufacturing, in the context of a comprehensive description of the plasmid manufacturing intellectual property landscape. Strategies for plasmid manufacturers to develop or in-license key plasmid manufacturing technologies are described with the endpoint of efficiently producing kg quantities of plasmid DNA of a quality that meets anticipated European and FDA quality specifications for commercial plasmid products.
Keywords: Plasmid, DNA vaccine, gene therapy, fermentation, purification, alkaline lysis, downstream processing
Recent Patents on Biotechnology
Title: Plasmid DNA Manufacturing Technology
Volume: 1 Issue: 2
Author(s): Aaron E. Carnes and James A. Williams
Affiliation:
Keywords: Plasmid, DNA vaccine, gene therapy, fermentation, purification, alkaline lysis, downstream processing
Abstract: Today, plasmid DNA is becoming increasingly important as the next generation of biotechnology products (gene medicines and DNA vaccines) make their way into clinical trials, and eventually into the pharmaceutical marketplace. This review summarizes recent patents and patent applications relating to plasmid manufacturing, in the context of a comprehensive description of the plasmid manufacturing intellectual property landscape. Strategies for plasmid manufacturers to develop or in-license key plasmid manufacturing technologies are described with the endpoint of efficiently producing kg quantities of plasmid DNA of a quality that meets anticipated European and FDA quality specifications for commercial plasmid products.
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Cite this article as:
Carnes E. Aaron and Williams A. James, Plasmid DNA Manufacturing Technology, Recent Patents on Biotechnology 2007; 1 (2) . https://dx.doi.org/10.2174/187220807780809436
DOI https://dx.doi.org/10.2174/187220807780809436 |
Print ISSN 1872-2083 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-4012 |
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