DNA Repair in HIV-1 Infection: A Case for Inhibitors of Cellular Co-Factors?

Title: DNA Repair in HIV-1 Infection: A Case for Inhibitors of Cellular Co-Factors?

Volume: 4 Issue: 4

Author(s): Rene Daniel

Affiliation:

Keywords: non-homologous end joining, post-integration repair, integration, ATR, ATM, DNA-PK, HIV-1

Abstract: At each step of its life-cycle, human immunodeficiency virus type 1 (HIV-1) interacts with cellular proteins. In some cases, such as the cellular cytidine deaminase APOBEC3G, cellular proteins repress HIV-1 replication. In other cases, cellular proteins serve as essential co-factors, and inhibition of their function blocks HIV-1 replication. This review explores the opportunities for anti-HIV-1 therapy that stem from the recent discoveries that cellular proteins, which are involved in double-strand break DNA repair, are also required for completion of integration of HIV-1 DNA into host cell DNA.

Cite this article as:

Daniel Rene, DNA Repair in HIV-1 Infection: A Case for Inhibitors of Cellular Co-Factors?, Current HIV Research 2006; 4 (4) . https://dx.doi.org/10.2174/157016206778560027