Abstract
Microwave assisted solid phase synthesis of imidazo[1,2-a]pyridines and imidazo[1,2-a]pyrimidines by the treatment of polymer-bound α-bromoketone with various 2-aminopyridines or 2-aminopyrimidines was achieved. Functionalizations of the 3-positions were realized by the treatment of polymer-bound 3-iodoimidazo[1,2-a]pyridine or polymer-bound 3-iodoimidazo[1,2-a]pyrimidine with various boronic acids under Suzuki-Miyaura reaction conditions. 6- Position of polymer-bound imidazo[1,2-a]pyridine was also functionalized using Suzuki-Miyaura cross-coupling reaction
Keywords: Imidazo[1,2-a]pyridine imidazo[1,2-a]pyrimidine, microwave irradiations, solid phase synthesis, Suzuki-Miyaura cross-coupling, antiviral, antiulcer, antibacterial, antifungal, receptor ligands, calcium channel blocker
Letters in Organic Chemistry
Title: Synthesis and Functionalization of Imidazo[1,2-a]Pyridines and Imidazo[1,2-a]Pyrimidines on Solid Phase Using Suzuki-Miyaura Cross-Coupling Reactions
Volume: 9 Issue: 2
Author(s): Said El Kazzouli, Sabine Berteina-Raboin, Abderrahim Mouaddib and Gerald Guillaumet
Affiliation:
Keywords: Imidazo[1,2-a]pyridine imidazo[1,2-a]pyrimidine, microwave irradiations, solid phase synthesis, Suzuki-Miyaura cross-coupling, antiviral, antiulcer, antibacterial, antifungal, receptor ligands, calcium channel blocker
Abstract: Microwave assisted solid phase synthesis of imidazo[1,2-a]pyridines and imidazo[1,2-a]pyrimidines by the treatment of polymer-bound α-bromoketone with various 2-aminopyridines or 2-aminopyrimidines was achieved. Functionalizations of the 3-positions were realized by the treatment of polymer-bound 3-iodoimidazo[1,2-a]pyridine or polymer-bound 3-iodoimidazo[1,2-a]pyrimidine with various boronic acids under Suzuki-Miyaura reaction conditions. 6- Position of polymer-bound imidazo[1,2-a]pyridine was also functionalized using Suzuki-Miyaura cross-coupling reaction
Export Options
About this article
Cite this article as:
El Kazzouli Said, Berteina-Raboin Sabine, Mouaddib Abderrahim and Guillaumet Gerald, Synthesis and Functionalization of Imidazo[1,2-a]Pyridines and Imidazo[1,2-a]Pyrimidines on Solid Phase Using Suzuki-Miyaura Cross-Coupling Reactions, Letters in Organic Chemistry 2012; 9 (2) . https://dx.doi.org/10.2174/157017812800221753
DOI https://dx.doi.org/10.2174/157017812800221753 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
The Role of PDE5-Inhibitors in Cardiopulmonary Disorders: From Basic Evidence to Clinical Development
Current Medicinal Chemistry Wasp Venom Toxins as a Potential Therapeutic Agent
Protein & Peptide Letters Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) and LDL Lowering in the Contemporary Management of Dyslipidemia
Cardiovascular & Hematological Agents in Medicinal Chemistry The Promises and Challenges of the Use of Genomics in the Prescription of Exercise in Hypertension
Current Hypertension Reviews Omega-3 Polyunsaturated Fatty Acids and Cancer
Anti-Cancer Agents in Medicinal Chemistry Perspectives on Chemopreventive and Therapeutic Potential of Curcumin Analogs in Medicinal Chemistry
Mini-Reviews in Medicinal Chemistry Reactive Oxygen-Induced Cardiac Intracellular Pathways During Ischemia and Reperfusion
Current Signal Transduction Therapy Recent Developments in Pharmacologic Prophylaxis of Atrial Fibrillation in Patients Undergoing Surgical Revascularization
Cardiovascular & Hematological Agents in Medicinal Chemistry Selective Inhibitors of Zinc-Dependent Histone Deacetylases. Therapeutic Targets Relevant to Cancer
Current Pharmaceutical Design Molecular Imaging: Its Application In Cardiovascular Diagnosis
Current Pharmaceutical Design N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP): Potential target molecule in research of heart, kidney and brain
Current Pharmaceutical Design L-Carnitine - Metabolic Functions and Meaning in Humans Life
Current Drug Metabolism The Role of P2Y<sub>12</sub> Receptor and Activated Platelets During Inflammation
Current Drug Targets The Fabry Cardiomyopathy - Diagnostic Approach and Current Treatment
Current Pharmaceutical Design Inhibitors of Steroidal Cytochrome P450 Enzymes as Targets for Drug Development
Recent Patents on Anti-Cancer Drug Discovery Inflammatory Biomarkers Predicting Events in Atherosclerosis
Current Medicinal Chemistry Computer-Assisted Methods in Chemical Toxicity Prediction
Mini-Reviews in Medicinal Chemistry Potential Therapeutic Targets in Cirrhotic Cardiomyopathy
Cardiovascular & Hematological Disorders-Drug Targets LPS In Patients With Left Ventricular Dysfunction Of Ischemic And Non-Ischemic Origin
Cardiovascular & Hematological Disorders-Drug Targets Biochemical, Enzymatic and Molecular Properties of Renin/Prorenin Mediated by (Pro)Renin Receptor
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued)