Synthesis of 2,4,6-Trichlorophenyl Hydrazones and their Inhibitory Potential Against Glycation of Protein

Title: Synthesis of 2,4,6-Trichlorophenyl Hydrazones and their Inhibitory Potential Against Glycation of Protein

Volume: 7 Issue: 6

Author(s): Khalid Mohammed Khan, Zarbad Shah, Viqar Uddin Ahmad, Momin Khan, Muhammad Taha, Fazal Rahim, Humera Jahan, Shahnaz Perveen and M. Iqbal Choudhary

Affiliation:

Keywords: 2,4,6-trichlorophenyl hydrazones, Schiff bases, Antiglycation, AGEPs, Glycation of protein., vitro antiglycation, spectroscopic, techniques, chemotherapeutic Schiff, antibacterial, antiproliferative

Abstract: 2,4,6-Trichlorophenyl hydrazones 1-35 were synthesized and their in vitro antiglycation potential was evaluated. Compounds 14 (IC50 = 27.2 ± 0.00 μM), and 18 (IC50 = 55.7 ± 0.00 μM) showed an excellent activity against glycation of protein, better than the standard (rutin, IC50 = 70 ± 0.50 μM). This study thus identified a novel series of antiglycation agents. A structure-activity relationship has been studied, and all the compounds were characterized by spectroscopic techniques.

Cite this article as:

Mohammed Khan Khalid, Shah Zarbad, Uddin Ahmad Viqar, Khan Momin, Taha Muhammad, Rahim Fazal, Jahan Humera, Perveen Shahnaz and Iqbal Choudhary M., Synthesis of 2,4,6-Trichlorophenyl Hydrazones and their Inhibitory Potential Against Glycation of Protein, Medicinal Chemistry 2011; 7 (6) . https://dx.doi.org/10.2174/157340611797928415