Advances in Structural Modifications and Biological Activities of Berberine: An Active Compound in Traditional Chinese Medicine

Title: Advances in Structural Modifications and Biological Activities of Berberine: An Active Compound in Traditional Chinese Medicine

Volume: 11 Issue: 13

Author(s): Z.-J. Huang, Y. Zeng, P. Lan, P.-H. Sun and W.-M. Chen

Affiliation:

Keywords: Berberine, structural modification, biological activities, isoquinoline alkaloid, Chinese herbs, Coptidis Rhizome, antitumor, antimicrobial, anti-Alzheimer's disease, antihyperglycemic, antimalaria

Abstract: Berberine is an isoquinoline alkaloid isolated from Chinese herbs such as Coptidis Rhizome. This paper is a systematic review of the structural modifications of berberine for different biological activities such as antitumor, antimicrobial, anti-Alzheimer's disease, antihyperglycemic, anti-inflammatory and antimalaria. The current review would provide some useful information for further studies on structural modification of berberine for discovering new drug leads.

Cite this article as:

Huang Z.-J., Zeng Y., Lan P., Sun P.-H. and Chen W.-M., Advances in Structural Modifications and Biological Activities of Berberine: An Active Compound in Traditional Chinese Medicine, Mini-Reviews in Medicinal Chemistry 2011; 11 (13) . https://dx.doi.org/10.2174/138955711797655362