Reciprocal Interactions Between Wakefulness and Sleep Influence Global and Regional Brain Activity

Title: Reciprocal Interactions Between Wakefulness and Sleep Influence Global and Regional Brain Activity

Volume: 11 Issue: 19

Author(s): Vincenzo Muto, Laura Mascetti, Luca Matarazzo, Caroline Kusse, Ariane Foret, Anahita Shaffii-Le Bourdiec, Gilles Vandewalle, Derk Jan Dijk and Pierre Maquet

Affiliation:

Keywords: Sleep, slow waves, spindles, REM sleep, circadian rhythms, cognition, memory, neuroimaging, circadian signals, memory consolidation, regional modifications of brain, homeostatic regulation, core components, posterior cingulate cortices

Abstract: Reciprocal interactions between wakefulness and sleep substantially influence human brain function in both states of vigilance. On the one hand, there is evidence that regionally-specialized brain activity during wakefulness is modulated by the interaction between a local use-dependent buildup of homeostatic sleep pressure and circadian signals. On the other hand, brain activity during sleep, although mainly constrained by genuine sleep oscillations, shows wakedependent regionally-specific modulations, which are involved in the dissipation of local homeostatic sleep pressure and memory consolidation.

Cite this article as:

Muto Vincenzo, Mascetti Laura, Matarazzo Luca, Kusse Caroline, Foret Ariane, Shaffii-Le Bourdiec Anahita, Vandewalle Gilles, Jan Dijk Derk and Maquet Pierre, Reciprocal Interactions Between Wakefulness and Sleep Influence Global and Regional Brain Activity, Current Topics in Medicinal Chemistry 2011; 11 (19) . https://dx.doi.org/10.2174/156802611797470358