Abstract
Since the discovery of cisplatin, the search for diagnostic or therapeutic agents based on other metals, has expanded intensively owing to the numerous possibilities offered by coordination chemistry. This mini-review focuses on recent advances in the search for RuII polyazaaromatic complexes of potential interest as molecular tools applied to cellular diagnostics or as specific cellular photo-reagents for future biomedical applications. The interaction of RuII polyazaaromatic complexes with living cells is reported, as well as the photo-reaction mechanisms of photo-oxidizing RuII complexes with nucleic acids. The novel strategies currently developed to improve their reactivity and specificity towards DNA, more particularly in the gene-silencing framework, are also discussed.
Keywords: Diagnostic agent, DNA, oligonucleotide, photo-therapeutic agent, ruthenium, living cells, specific cellular photo-reagents, photo-oxidizing RuII complexes, nucleic acids, luminescent probes, luminophores for biomolecules, hydrophobic complexes, emission wavelengths, cell-viability, gel electrophoresis analyses
Current Topics in Medicinal Chemistry
Title: What Does the Future Hold for Photo-Oxidizing RuII Complexes with Polyazaaromatic Ligands in Medicinal Chemistry?
Volume: 12 Issue: 3
Author(s): Jonathan Ghesquiere, Stephane Le Gac, Lionel Marcelis, Cecile Moucheron and Andree Kirsch - De Mesmaeker
Affiliation:
Keywords: Diagnostic agent, DNA, oligonucleotide, photo-therapeutic agent, ruthenium, living cells, specific cellular photo-reagents, photo-oxidizing RuII complexes, nucleic acids, luminescent probes, luminophores for biomolecules, hydrophobic complexes, emission wavelengths, cell-viability, gel electrophoresis analyses
Abstract: Since the discovery of cisplatin, the search for diagnostic or therapeutic agents based on other metals, has expanded intensively owing to the numerous possibilities offered by coordination chemistry. This mini-review focuses on recent advances in the search for RuII polyazaaromatic complexes of potential interest as molecular tools applied to cellular diagnostics or as specific cellular photo-reagents for future biomedical applications. The interaction of RuII polyazaaromatic complexes with living cells is reported, as well as the photo-reaction mechanisms of photo-oxidizing RuII complexes with nucleic acids. The novel strategies currently developed to improve their reactivity and specificity towards DNA, more particularly in the gene-silencing framework, are also discussed.
Export Options
About this article
Cite this article as:
Ghesquiere Jonathan, Le Gac Stephane, Marcelis Lionel, Moucheron Cecile and Kirsch - De Mesmaeker Andree, What Does the Future Hold for Photo-Oxidizing RuII Complexes with Polyazaaromatic Ligands in Medicinal Chemistry?, Current Topics in Medicinal Chemistry 2012; 12 (3) . https://dx.doi.org/10.2174/156802612799079008
DOI https://dx.doi.org/10.2174/156802612799079008 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
Call for Papers in Thematic Issues
Medicinal Chemistry Advancement in Life-Threatening Diseases
The current issue will highlight concise reports that specify ground-breaking insights, including the novel discovery of drug targets and their action mechanism or drugs of novel classes. These are projected to encourage medicinal chemistry future efforts to address the most challenging medical needs. The current issue highlights further efforts to ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Development of Aptamer-Based Nanomaterials for Biological Analysis
Current Molecular Medicine Near-infrared Light Responsive Upconversion Nanoparticles for Imaging, Drug Delivery and Therapy of Cancers
Current Nanoscience Subject Index to Volume 5
Current Drug Metabolism Pharmacological Therapy of Pericardial Diseases
Current Pharmaceutical Design Synthesis of New Antibacterial Cubane-based Nanocomposite and its Application in Combination Cancer Therapy
Anti-Cancer Agents in Medicinal Chemistry Gold Nanoparticles Enhance the Toluidine Blue-Induced Lethal Photosensitisation of Staphylococcus aureus
Current Nanoscience Cancer Preventive Phytochemicals as Speed Breakers in Inflammatory Signaling Involved in Aberrant COX-2 Expression
Current Cancer Drug Targets Conjugation of Peptides to Antisense Interleukin-6 Via Click Chemistry
Current Medicinal Chemistry Purinergic Receptors and Pain
Current Pharmaceutical Design Classification of Malignant and Benign Micro Calcifications from Mammogram Using Optimized Cascading Classifier
Current Signal Transduction Therapy Anticancer Vitamin K3 Analogs: A Review
Anti-Cancer Agents in Medicinal Chemistry Patent Selections:
Recent Patents on Biomarkers Editorial [Hot Topic:Part-II Imaging and Treatment of Oncological Diseases (Guest Editor: J.F.W. Nijsen) ]
Anti-Cancer Agents in Medicinal Chemistry Apoptotic and Anti-Angiogenic Effects of Benzimidazole Compounds: Relationship with Oxidative Stress Mediated Ischemia/Reperfusion Injury in Rat Hind Limb
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Editorial [ Are Peptide Therapeutics the Future? Guest Editor: Sivaram Pillarisetti ]
Current Pharmaceutical Biotechnology Use of High-intensity Focused Ultrasound in the Management of Extra-abdominal Desmoid Tumors
Current Medical Imaging Editorial [Hot Topic: Drug Targets in Viral Infections (Guest Editor: Jean-Marc Sabatier)]
Infectious Disorders - Drug Targets Withdrawal Notice: The Prognostic Value of Prognostic Biomarkers in Esophageal Squamous Cell Carcinoma in Iranian Population
Current Cancer Therapy Reviews Overview of the Role of Macrophage Migration Inhibitory Factor (MIF) in Inflammatory Bowel Disease
Current Pharmaceutical Design ZnO Nanoparticles Catalyst in the Synthesis of Bioactive Fused Pyrimidines as Anti-breast Cancer Agents Targeting VEGFR-2
Medicinal Chemistry