New Insights into the Immune Response to Pneumococci

Title: New Insights into the Immune Response to Pneumococci

Volume: 7 Issue: 4

Author(s): Suzanna E.L. Temple and Phil Hansbro

Affiliation:

Keywords: Streptococcus pneumoniae, CD4+, CD8+, T cells, Immune Response, cellular immunity, phagocytosis, pneumococcal surface protein A, anti-capsular antibody, B-cells, Cytotoxic

Abstract: Infection by Streptococcus pneumoniae (the pneumococcus) is associated with enormous morbidity and mortality worldwide and this bacterium remains the commonest cause of pneumonia, meningitis and otitis media. While immunity to pneumococcal disease has been widely accepted to depend mainly on the humoral arm of the immune system recent studies have shown a critical role for cellular immunity, specifically T lymphocytes (T cells), that is independent of antibody, in the prevention and clearance of pneumococcal infection. Here we review the evidence that supports the importance of T cells, specifically CD4+, CD8+ and regulatory T cells, in host responses to pneumococcal infection.

Cite this article as:

E.L. Temple Suzanna and Hansbro Phil, New Insights into the Immune Response to Pneumococci, Current Respiratory Medicine Reviews 2011; 7 (4) . https://dx.doi.org/10.2174/157339811798281188