Synthesis and Antithrombotic Activity Study of Some New Thienopyridine Derivatives

Title: Synthesis and Antithrombotic Activity Study of Some New Thienopyridine Derivatives

Volume: 8 Issue: 6

Author(s): Nageswar R. Challa, Mahesh R. Ghanta and Pratap R. Padi

Affiliation:

Keywords: Antiplatelet agents, antithrombotic agents, in-vivo, thienopyridine, thrombus formation, pyridin, biphenyl, carboxylic acid, ylmethyl, hypertensive disorders

Abstract: During the course of our investigation in the field of thienopyridine based antithrombotic agents, we have identified and synthesized 4-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-ylmethyl)-biphenyl-2-carboxylic acid derivatives 5a-i, a thienopyridine derivative with good in vivo activity against thrombus formation. These findings prompted us to prepare new 4-(6,7-dihydro-4H-thieno[3,2-c]pyridin-5-ylmethyl)-biphenyl-2-carboxylic acid derivatives bearing different acid derivatives 5a-i in the hope of increasing activity and better understanding the influence of esters and amides on the thrombus formation.

Cite this article as:

R. Challa Nageswar, R. Ghanta Mahesh and R. Padi Pratap, Synthesis and Antithrombotic Activity Study of Some New Thienopyridine Derivatives, Letters in Organic Chemistry 2011; 8 (6) . https://dx.doi.org/10.2174/157017811796064476