Labeling Strategies with F-18 for Positron Emission Tomography Imaging

Title: Labeling Strategies with F-18 for Positron Emission Tomography Imaging

Volume: 7 Issue: 5

Author(s): Yonghong Gu, Dong Huang, Zhiguo Liu, Jiaguo Huang and Wenbin Zeng

Affiliation:

Keywords: Probe, fluorination, F-18, positron emission tomography (PET), molecular imaging, labeling chemistry, radiotracer, radiochemists, radiopharmaceuticals, solid-phase, microfluidics, microwave chemistry

Abstract: The labeling of probes with fluorine-18 [18F, β(+); 96.7%] continues to play a considerably important role in the development of positron emission tomography (PET) as a modality for both clinical research and clinical diagnoses. This review summarizes the strategies and recent developments in the fluorine-18 labeling of probes for PET imaging. Problems and issues relating to the practical production of fluorine-18 currently in widespread use are also discussed.

Cite this article as:

Gu Yonghong, Huang Dong, Liu Zhiguo, Huang Jiaguo and Zeng Wenbin, Labeling Strategies with F-18 for Positron Emission Tomography Imaging, Medicinal Chemistry 2011; 7 (5) . https://dx.doi.org/10.2174/157340611796799140