Quinoxaline 1,4-di-N-Oxide and the Potential for Treating Tuberculosis

Title: Quinoxaline 1,4-di-N-Oxide and the Potential for Treating Tuberculosis

Volume: 11 Issue: 2

Author(s): Esther Vicente, Raquel Villar, Silvia Perez-Silanes, Ignacio Aldana, Robert C. Goldman and Antonio Monge

Affiliation:

Keywords: Tuberculosis, quinoxaline, N-oxides, mycobacterium, drug-resistant, medicinal chemistry is, antitubercular drug properties, non-replicating mycobacteria, aerosol infection, drug resistance, HIV, compounds

Abstract: New drugs active against drug-resistant tuberculosis are urgently needed to extend the range of TB treatment options to cover drug resistant infections. Quinoxaline derivatives show very interesting biological properties (antibacterial, antiviral, anticancer, antifungal, antihelmintic, insecticidal) and evaluation of their medicinal chemistry is still in progress. In this review we report the properties and the recent developments of quinoxaline 1,4-di-N-oxide derivatives as potential anti-tuberculosis agents. Specific agents are reviewed that have excellent antitubercular drug properties, are active on drug resistant strains and non-replicating mycobacteria. The properties of select analogs that have in vivo activity in the low dose aerosol infection model in mice will be reviewed.

Cite this article as:

Vicente Esther, Villar Raquel, Perez-Silanes Silvia, Aldana Ignacio, C. Goldman Robert and Monge Antonio, Quinoxaline 1,4-di-N-Oxide and the Potential for Treating Tuberculosis, Infectious Disorders - Drug Targets 2011; 11 (2) . https://dx.doi.org/10.2174/187152611795589735