Antimalarial Activity of an N-Alkyl Diamine

Title: Antimalarial Activity of an N-Alkyl Diamine

Volume: 8 Issue: 4

Author(s): Nicolli B. de Souza, Carlos A. M. Rezende, Marcela S. Toledo, Davi C. Lagatta, Raphaela V. T. de Oliveira, Cristiane F. da Costa, Adilson D. da Silva, Marcio J. M. Alves, Sonia M. N. Cupolilo, Mauro V. de Almeida and Clarice Abramo

Affiliation:

Keywords: Antimalarial activity, Diamines, Malaria, Murine model, Plasmodium berghei, Polyamines, Lethal, Infectious Diseases, Protozoan Parasites, P. falciparum, P. vivax, P. malariae, P. Ovale, Trichomonas vaginalis, Trypanosoma cruzi

Abstract: We report in this work the antimalarial activity of N-dodecyl-ethylenediamine (NDEDA). This compound was tested in vivo in a Plasmodium berghei murine model using the 4-day suppressive test in two separate experiments and displayed a very good inhibition of parasite multiplication.

Cite this article as:

B. de Souza Nicolli, A. M. Rezende Carlos, S. Toledo Marcela, C. Lagatta Davi, V. T. de Oliveira Raphaela, F. da Costa Cristiane, D. da Silva Adilson, J. M. Alves Marcio, M. N. Cupolilo Sonia, V. de Almeida Mauro and Abramo Clarice, Antimalarial Activity of an N-Alkyl Diamine, Letters in Drug Design & Discovery 2011; 8 (4) . https://dx.doi.org/10.2174/157018011794839439

DOI https://dx.doi.org/10.2174/157018011794839439	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X