Abstract
Enteroviruses (EVs) are common and significant human pathogens in Asia. EV infections can cause a wide spectrum of acute diseases, including CNS complications. These EV infection-related CNS syndromes include acute flaccid paralysis, aseptic meningitis, encephalitis, and even death. Currently, there is no vaccine available for most EVs except for poliovirus; furthermore, there is a lack of clinical antiviral drugs for treating EV-related infections. These shortages reveal the need to develop potent compounds for treating enteroviral infections. This study summarizes the development of drugs for EV-related infections based on molecular targets blocking various steps in the viral replication cycle.
Keywords: Enterovirus, antiviral agent, therapy, inhibition, viral encephalitis, capsid inhibitor, protease inhibitor, polymerase inhibitor, CNS complications, EV infection-related CNS syndromes, acute flaccid paralysis, aseptic meningitis, encephalitis, poliovirus, viral replication cycle
Infectious Disorders - Drug Targets
Title: Drug Discovery in Enteroviral Infections
Volume: 11 Issue: 3
Author(s): Tzu-Chun Chen and Shin-Ru Shih
Affiliation:
Keywords: Enterovirus, antiviral agent, therapy, inhibition, viral encephalitis, capsid inhibitor, protease inhibitor, polymerase inhibitor, CNS complications, EV infection-related CNS syndromes, acute flaccid paralysis, aseptic meningitis, encephalitis, poliovirus, viral replication cycle
Abstract: Enteroviruses (EVs) are common and significant human pathogens in Asia. EV infections can cause a wide spectrum of acute diseases, including CNS complications. These EV infection-related CNS syndromes include acute flaccid paralysis, aseptic meningitis, encephalitis, and even death. Currently, there is no vaccine available for most EVs except for poliovirus; furthermore, there is a lack of clinical antiviral drugs for treating EV-related infections. These shortages reveal the need to develop potent compounds for treating enteroviral infections. This study summarizes the development of drugs for EV-related infections based on molecular targets blocking various steps in the viral replication cycle.
Export Options
About this article
Cite this article as:
Chen Tzu-Chun and Shih Shin-Ru, Drug Discovery in Enteroviral Infections, Infectious Disorders - Drug Targets 2011; 11 (3) . https://dx.doi.org/10.2174/187152611795768060
DOI https://dx.doi.org/10.2174/187152611795768060 |
Print ISSN 1871-5265 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3989 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Vaccine Development for Alzheimers Disease
Current Pharmaceutical Design Advancement in Nanoparticle-based Biosensors for Point-of-care <i>In vitro</i> Diagnostics
Current Topics in Medicinal Chemistry Quantitative and Mechanistic Studies of Aβ Immunotherapy
CNS & Neurological Disorders - Drug Targets Astrocytes: Adhesion Molecules and Immunomodulation
Current Drug Targets Cellular Delivery In Vivo of siRNA-Based Therapeutics
Current Pharmaceutical Design Ebola Virus Altered Innate and Adaptive Immune Response Signalling Pathways: Implications for Novel Therapeutic Approaches
Infectious Disorders - Drug Targets Regulation of Angiogenesis by the Small Heat Shock Protein αB-Crystallin
Current Angiogenesis (Discontinued) Gene Therapy to Improve Pancreatic Islet Transplantation for Type 1 Diabetes Mellitus
Current Diabetes Reviews Combining Drug and Immune Therapy: A Potential Solution to Drug Resistance and Challenges of HIV Vaccines?
Current HIV Research Autoantibodies in Autoimmune Diseases
Current Pharmaceutical Design Angiotensin-Converting Enzyme 2 Roles in the Pathogenesis of COVID-19
Current Hypertension Reviews Early Diagnosis of Multiple Sclerosis Based on Optical and Electrochemical Biosensors: Comprehensive Perspective
Current Analytical Chemistry Recent Advances in Targeting Viral Proteases for the Discovery of Novel Antivirals
Current Topics in Medicinal Chemistry SARS Coronavirus Anti-Infectives
Recent Patents on Anti-Infective Drug Discovery Acanthamoeba-Bacteria: A Model to Study Host Interaction with Human Pathogens
Current Drug Targets Evasion of Ribonuclease Inhibitor as a Determinant of Ribonuclease Cytotoxicity
Current Pharmaceutical Biotechnology Developments in High-Yield System Expressed Vaccines and Immunotherapy
Recent Patents on Biotechnology Fibrinogen Signal Transduction as a Mediator and Therapeutic Target in Inflammation:Lessons from Multiple Sclerosis
Current Medicinal Chemistry Therapeutical Potential of CB<sub>2</sub> Receptors in Immune-Related Diseases
Current Molecular Pharmacology Editorial [ NeuroAIDS: A Neuroscience Problem with Global Impact ]
Current HIV Research