Abstract
Synthesis of piperazinyl-substituted oxazolopyridine and benzoxazole was achieved in three steps starting from aminophenol and carbon disulfide. Condensation of aminophenols with carbon disulfide in ethanol using potassium hydroxide as catalyst gave the required benzoxazole thiol in one step. Treatment of the thiol with piperazine and substituted piperazine derivatives in toluene furnished the titled compounds in good yield. We introduced halogen substitution in the pendant arm of the piperazine derivatives for versatile functionalization. We report the synthesis and characterization of these compounds using high resolution NMR techniques.
Keywords: Synthesis, characterization, oxazolopyridines, benzoxazole, piperazines
Letters in Organic Chemistry
Title: Synthesis and Characterization of Oxazolopyridine and Benzoxazole Derivatives
Volume: 7 Issue: 7
Author(s): T. K. Venkatachalam, G. K. Pierens and D. C. Reutens
Affiliation:
Keywords: Synthesis, characterization, oxazolopyridines, benzoxazole, piperazines
Abstract: Synthesis of piperazinyl-substituted oxazolopyridine and benzoxazole was achieved in three steps starting from aminophenol and carbon disulfide. Condensation of aminophenols with carbon disulfide in ethanol using potassium hydroxide as catalyst gave the required benzoxazole thiol in one step. Treatment of the thiol with piperazine and substituted piperazine derivatives in toluene furnished the titled compounds in good yield. We introduced halogen substitution in the pendant arm of the piperazine derivatives for versatile functionalization. We report the synthesis and characterization of these compounds using high resolution NMR techniques.
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Cite this article as:
K. Venkatachalam T., K. Pierens G. and C. Reutens D., Synthesis and Characterization of Oxazolopyridine and Benzoxazole Derivatives, Letters in Organic Chemistry 2010; 7 (7) . https://dx.doi.org/10.2174/157017810793362352
DOI https://dx.doi.org/10.2174/157017810793362352 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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