Bioprecursor Prodrugs: Molecular Modification of the Active Principle

Title: Bioprecursor Prodrugs: Molecular Modification of the Active Principle

Volume: 10 Issue: 14

Author(s): Ganesh R. Kokil and Prarthana V. Rewatkar

Affiliation:

Keywords: Bioprecursor prodrugs, active metabolites, oxidative activation, glucuronic acid conjugation, bioreductive alkylation, prodrugs, proagent, O-demethylated metabolite of phenacetin, phenacetin, OXIDATION, Cytochrome P450 Mono-Oxygenase, NADPH-CYP reductase, CYP enzymes, xenobiotics, Flavin-Containing Monooxygenase System, FMO family, lipophilic compounds, Monoamine Oxidase, neurotransmitter amines, clorgyline, serotonin, L-deprenyl, oxidize dopamine, tyramine, octopamine, hydrogen peroxide, NADPH-cytochrome P450 reductase, NADH-putidaredoxin reductase, Nabumetone, Dexpathenol, 3-pyridine methanol, mitomycin, nitrogen mustard, omeprazole, Sulindac, SAH 51-641, acyl CoA ligase, gluconeogenesis, aroylpropionic acids, aryl acetic acid, aroylpropionic acid, bucloxic acid, indomethacin, Idoxuridine, thymidine kinase, Methyltransferase, Glutathione S-Transferases, Sulfotransferases System, N-Acetyltransferases System, UDP-Glucuronosyltransferases, UDP, Minoxidil, paclitaxel

Abstract: A large number of therapeutic medications have undesirable properties that may generate pharmacological, pharmaceutical, or pharmacokinetic barriers in clinical drug applications. Metabolism of drugs by Phase-I & Phase-II metabolic pathways for possibility of active metabolites, which could in turn useful for rational designing of bioprecursor prodrugs of the active principle of interest. This review summarizes various approaches & development of drugs, namely bioprecursor prodrugs and active metabolites related to bioprecursor prodrugs.

Cite this article as:

R. Kokil Ganesh and V. Rewatkar Prarthana, Bioprecursor Prodrugs: Molecular Modification of the Active Principle, Mini-Reviews in Medicinal Chemistry 2010; 10 (14) . https://dx.doi.org/10.2174/138955710793564179