Recent Advances in the Development of Small-molecule CCR5 Inhibitors for HIV

Title: Recent Advances in the Development of Small-molecule CCR5 Inhibitors for HIV

Volume: 10 Issue: 13

Author(s): Tao Liu, Zhiyong Weng, Xiaowu Dong and Yongzhou Hu

Affiliation:

Keywords: HIV, Entry, Co-receptor, CCR5, Small-molecule inhibitor, Maraviroc

Abstract: CCR5 (C-C chemokine receptor type 5) is a chemokine receptor that has been identified as a major HIV coreceptor in viral entry and therefore is a highly validated target for the development of new anti-HIV drugs. Here, we discuss the insights gained so far relevant to the development of small-molecule CCR5 inhibitors for the treatment of HIV, and highlight small-molecule CCR5 inhibitors that are currently under preclinical and clinical trials.

Cite this article as:

Liu Tao, Weng Zhiyong, Dong Xiaowu and Hu Yongzhou, Recent Advances in the Development of Small-molecule CCR5 Inhibitors for HIV, Mini-Reviews in Medicinal Chemistry 2010; 10 (13) . https://dx.doi.org/10.2174/13895575110091277