Structure, Function and Inhibition of Bcl-2 Family Proteins: A New Target for Anti-Tumor Agents

Title: Structure, Function and Inhibition of Bcl-2 Family Proteins: A New Target for Anti-Tumor Agents

Volume: 9 Issue: 14

Author(s): Guizhi Xiao, Hao Fang, Chengguo Xing and Wenfang Xu

Affiliation:

Keywords: Apoptosis, Bcl-2, structure, function, inhibitors, anti-tumor

Abstract: Proteins of Bcl-2(B-cell lymphoma-2) family are key regulators of programmed cell death. Scientist found that some members of this family are over-expressed in malignant tumors and influence the sensitivity of tumor cells to chemotherapy and radiotherapy. This report reviews the recent progress of structures, functions and inhibition of Bcl-2 family proteins, especially the development of Bcl-2 inhibitors in past decades as anticancer agents.

Cite this article as:

Xiao Guizhi, Fang Hao, Xing Chengguo and Xu Wenfang, Structure, Function and Inhibition of Bcl-2 Family Proteins: A New Target for Anti-Tumor Agents, Mini-Reviews in Medicinal Chemistry 2009; 9 (14) . https://dx.doi.org/10.2174/138955709791012238