Abstract
A series of seventeen disubstituted N-acylhydrazone pyrazinecarbohydrazide (4-20) have been synthesized and evaluated for their cell viabilities, were compared to another monosubstituted derivatives previously synthesized by us. This study indicated that the position and nature of the substituents in the aromatic ring influence the cytotoxicity of this series.
Keywords: Pyrazine, N-acylhydrazones, Tuberculosis, Drugs
Letters in Drug Design & Discovery
Title: Synthesis and Cytotoxic Evaluation of Disubstituted N-Acylhydrazones Pyrazinecarbohydrazide Derivatives
Volume: 7 Issue: 4
Author(s): Marcelle de L. Ferreira, Andre L.P. Candea, Maria das Gracas M. de O. Henriques, Carlos R. Kaiser, Camilo H. da S. Lima and Marcus V.N. de Souza
Affiliation:
Keywords: Pyrazine, N-acylhydrazones, Tuberculosis, Drugs
Abstract: A series of seventeen disubstituted N-acylhydrazone pyrazinecarbohydrazide (4-20) have been synthesized and evaluated for their cell viabilities, were compared to another monosubstituted derivatives previously synthesized by us. This study indicated that the position and nature of the substituents in the aromatic ring influence the cytotoxicity of this series.
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Cite this article as:
de L. Ferreira Marcelle, Candea L.P. Andre, de O. Henriques M. Maria das Gracas, Kaiser R. Carlos, da S. Lima H. Camilo and de Souza V.N. Marcus, Synthesis and Cytotoxic Evaluation of Disubstituted N-Acylhydrazones Pyrazinecarbohydrazide Derivatives, Letters in Drug Design & Discovery 2010; 7 (4) . https://dx.doi.org/10.2174/157018010790945814
DOI https://dx.doi.org/10.2174/157018010790945814 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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