Abstract
A series of chrysin derivatives were prepared from 2-hydroxyacetophenone, 2,4-dihydroxyacetophenone, 2,4,6- trihydroxy- acetophenone, using modified Baker-Venkataraman transformation. Their anticancer activities in vitro were evaluated by the standard MTT method. The results of biological test showed that some of chrysin derivatives showed stronger anticancer activity than 5-fluorouracil.
Medicinal Chemistry
Title: Synthesis and Preliminary Biological Evaluation of Chrysin Derivatives as Potential Anticancer Drugs
Volume: 6 Issue: 1
Author(s): Xing Zheng, Fei Fei Zhao, Yun Mei Liu, Xu Yao, Zi Tong Zheng, Xing Luo and Duan Fang Liao
Affiliation:
Abstract: A series of chrysin derivatives were prepared from 2-hydroxyacetophenone, 2,4-dihydroxyacetophenone, 2,4,6- trihydroxy- acetophenone, using modified Baker-Venkataraman transformation. Their anticancer activities in vitro were evaluated by the standard MTT method. The results of biological test showed that some of chrysin derivatives showed stronger anticancer activity than 5-fluorouracil.
Export Options
About this article
Cite this article as:
Zheng Xing, Zhao Fei Fei, Mei Liu Yun, Yao Xu, Zheng Zi Tong, Luo Xing and Liao Duan Fang, Synthesis and Preliminary Biological Evaluation of Chrysin Derivatives as Potential Anticancer Drugs, Medicinal Chemistry 2010; 6 (1) . https://dx.doi.org/10.2174/157340610791208763
DOI https://dx.doi.org/10.2174/157340610791208763 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Positron Emission Tomography: Applications In Drug Discovery and Drug Development
Current Topics in Medicinal Chemistry Alterations of Sex Differentiation in Males: From Candidate Genes to Diagnosis and Treatments
Current Pharmaceutical Design Drugs in Newborn Resuscitation: The More We Learn the Least We Use
Current Medicinal Chemistry Pharmacophore and Docking Guided Virtual Screening Study for Discovery of Type I Inhibitors of VEGFR-2 Kinase
Current Computer-Aided Drug Design Adenosine and ATP Receptors in the Brain
Current Topics in Medicinal Chemistry Mitochondrial Respiration in the Platelets of Patients with Alzheimer’s Disease
Current Alzheimer Research Natural Therapies of the Inflammatory Bowel Disease: The Case of Rutin and its Aglycone, Quercetin
Mini-Reviews in Medicinal Chemistry Asymmetric Dimethylarginine (ADMA): A Promising Biomarker for Cardiovascular Disease?
Current Topics in Medicinal Chemistry Neem-Borne Molecules as Eco-Friendly Control Tools Against Mosquito Vectors of Economic Importance
Current Organic Chemistry HSP90 Inhibitors: Current Development and Potential in Cancer Therapy
Recent Patents on Anti-Cancer Drug Discovery Role of Dietary Fiber in Formation and Prevention of Small Intestinal Ulcers Induced by Nonsteroidal Anti-Inflammatory Drug
Current Pharmaceutical Design Inflammatory Bowel Disease: Etiology, Pathogenesis and Current Therapy
Current Pharmaceutical Design Seek and Destroy: The Use of Natural Compounds for Targeting the Molecular Roots of Cancer
Current Drug Targets Obesity and Asthma
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued) Recent Advances in Drug Delivery: Potential and Limitations of Carbon Nanotubes
Recent Patents on Drug Delivery & Formulation Phosphodiesterase Type 5 Inhibitors: Unmet Needs
Current Pharmaceutical Design Extracellular Matrix Remodeling in Hypertension
Current Hypertension Reviews Porphyrin Photosensitised Processes in the Prevention and Treatment of Water- and Vector-Borne Diseases
Current Medicinal Chemistry Adopting Network Pharmacology for Cancer Drug Discovery
Current Drug Discovery Technologies Niacin: From Mechanisms of Action to Therapeutic Uses
Mini-Reviews in Medicinal Chemistry