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Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1573-4064
ISSN (Online): 1875-6638

Synthesis and Preliminary Biological Evaluation of Chrysin Derivatives as Potential Anticancer Drugs

Author(s): Xing Zheng, Fei Fei Zhao, Yun Mei Liu, Xu Yao, Zi Tong Zheng, Xing Luo and Duan Fang Liao

Volume 6, Issue 1, 2010

Page: [6 - 8] Pages: 3

DOI: 10.2174/157340610791208763

Price: $65

Abstract

A series of chrysin derivatives were prepared from 2-hydroxyacetophenone, 2,4-dihydroxyacetophenone, 2,4,6- trihydroxy- acetophenone, using modified Baker-Venkataraman transformation. Their anticancer activities in vitro were evaluated by the standard MTT method. The results of biological test showed that some of chrysin derivatives showed stronger anticancer activity than 5-fluorouracil.

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