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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Non-Globular Structures of Tandem Repeats in Proteins

Author(s): Norio Matsushima, Takanori Tanaka and Robert H. Kretsinger

Volume 16, Issue 11, 2009

Page: [1297 - 1322] Pages: 26

DOI: 10.2174/092986609789353745

Price: $65

Abstract

There are two classes of tandem repeats in proteins - globular and non-globular. There are two subclasses of non-globular repeats. The first, such as collagen, form stable helices. Members of the second are flexible and somewhat disordered both in vitro and in vivo. This review focuses on this second subclass.

Keywords: Tandem repeats, intrinsically unstructured protein, structural change, ligand interaction, rapid evolution, concerted evolution


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