QSAR study on N- (Aryl)-4-(Azolylethyl) Thiazole-5-Carboxamides: Novel Potent Inhibitors of VEGF Receptors I and II

Title: QSAR study on N- (Aryl)-4-(Azolylethyl) Thiazole-5-Carboxamides: Novel Potent Inhibitors of VEGF Receptors I and II

Volume: 5 Issue: 5

Author(s): Asha Patel, C. Karthikeyan, N. S. Hari Narayana Moorthy and Piyush Trivedi

Affiliation:

Keywords: QSAR, VEGF receptor, Topological descriptors

Abstract: QSAR study on N- (Aryl)-4-(azolylethyl) thiazole-5-carboxamides analogues, which are novel potent inhibitor of VEGF receptor II and I, were performed using topological, electronic and physicochemical descriptors. The results obtained demonstrate in detail, which specify that topological descriptors of the compounds play a significant role in developing QSAR models. The significance of presence and absence of substituents on particular position is successfully explored with the help of indicator variables. The results are critically discussed on the basis of multiple linear regression parameters.

Cite this article as:

Patel Asha, Karthikeyan C., Hari Narayana Moorthy S. N. and Trivedi Piyush, QSAR study on N- (Aryl)-4-(Azolylethyl) Thiazole-5-Carboxamides: Novel Potent Inhibitors of VEGF Receptors I and II, Medicinal Chemistry 2009; 5 (5) . https://dx.doi.org/10.2174/157340609789117813