Abstract
We report in this work the antibacterial evaluation of 12 lipophilic fluoroquinolone derivatives containing diaminoalkyl side chains at C-7 position. The compounds were investigated against 15 bacterial strains including Gramnegative and Gram-positive species of clinical and microbiological importance. Three compounds (5, 10 and 11) were as active as or more efficient than gatifloxacin against Gram-positive bacteria M. lentus. When compared with gatifloxacin compound 10 was 16 times more active. Two compounds (11 and 12) were twice more active than the reference compound against S. aureus.
Keywords: Fluoroquinolones, lipophilicity, antibacterial activity, gatifloxacin, moxifloxacin, diamines, alkyl chains
Medicinal Chemistry
Title: Antibacterial Activity of Lipophilic Fluoroquinolone Derivatives
Volume: 5 Issue: 5
Author(s): Camila G. de Almeida, Claudio G. Diniz, Vania L. Silva, Mauricio F. Saraiva, Mireille Le Hyaric and Mauro V. de Almeida
Affiliation:
Keywords: Fluoroquinolones, lipophilicity, antibacterial activity, gatifloxacin, moxifloxacin, diamines, alkyl chains
Abstract: We report in this work the antibacterial evaluation of 12 lipophilic fluoroquinolone derivatives containing diaminoalkyl side chains at C-7 position. The compounds were investigated against 15 bacterial strains including Gramnegative and Gram-positive species of clinical and microbiological importance. Three compounds (5, 10 and 11) were as active as or more efficient than gatifloxacin against Gram-positive bacteria M. lentus. When compared with gatifloxacin compound 10 was 16 times more active. Two compounds (11 and 12) were twice more active than the reference compound against S. aureus.
Export Options
About this article
Cite this article as:
de Almeida G. Camila, Diniz G. Claudio, Silva L. Vania, Saraiva F. Mauricio, Le Hyaric Mireille and de Almeida V. Mauro, Antibacterial Activity of Lipophilic Fluoroquinolone Derivatives, Medicinal Chemistry 2009; 5 (5) . https://dx.doi.org/10.2174/157340609789117859
DOI https://dx.doi.org/10.2174/157340609789117859 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Adenovirus-based Immunotherapy for Prostate Cancer
Current Cancer Therapy Reviews Danger-Detector NKG2D: Immunosurveillance of Induced Self and Modulation by Cytokines and Soluble Ligands
Current Medicinal Chemistry - Anti-Inflammatory & Anti-Allergy Agents Impurity Profiling-A Significant Approach in Pharmaceuticals
Current Pharmaceutical Analysis Role of Lipopolysaccharides in Potential Applications of Nanocarrier Systems
Current Pharmaceutical Design IO Nation: The Rise of Immuno-Oncology
Current Pharmacogenomics and Personalized Medicine Label-Free Cell Phenotypic Drug Discovery
Combinatorial Chemistry & High Throughput Screening Focusing on DNA Repair and Damage Tolerance Mechanisms in Mycobacterium tuberculosis: An Emerging Therapeutic Theme
Current Topics in Medicinal Chemistry Gene Cloning and Homology Modeling of the 3-Oxoacyl-ACP Synthase from Aeromonas hydrophila for Drug Discovery
Letters in Drug Design & Discovery Smart Biodecorated Hybrid Nanoparticles
Current Bionanotechnology (Discontinued) Leishmanicidal Activity of New Megazol Derivatives
Medicinal Chemistry A Systematic Review of Lifestyle Modification and Glucose Intolerance in the Prevention of Type 2 Diabetes
Current Diabetes Reviews Current and Future Pharmaceutical Therapy for Rheumatoid Arthritis
Current Pharmaceutical Design Isoquinoline Alkaloids and Their Antiviral, Antibacterial, and Antifungal Activities and Structure-activity Relationship
Current Organic Chemistry P2X7 Receptors: Channels, Pores and More
CNS & Neurological Disorders - Drug Targets Angiotensin-Converting Enzyme 2 Roles in the Pathogenesis of COVID-19
Current Hypertension Reviews Energy Provisioning and Inflammasome Activation: The Pivotal Role of AMPK in Sterile Inflammation and Associated Metabolic Disorders
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Monoclonal Antibodies in Allergy; Updated Applications and Promising Trials
Recent Patents on Inflammation & Allergy Drug Discovery Colloidal Drug Delivery Systems in Vaccine Delivery
Current Drug Targets Lung Cancer Chemotherapy, New Treatment and Related Patents
Recent Patents on Anti-Cancer Drug Discovery Contemporary Progress in the Synthesis and Reaction of 2-Arylbenzothiazole: A Review
Current Organic Chemistry