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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Rho Kinase (ROCK) Inhibitors and Their Application to Inflammatory Disorders

Author(s): Philip V. LoGrasso and Yangbo Feng

Volume 9, Issue 8, 2009

Page: [704 - 723] Pages: 20

DOI: 10.2174/156802609789044452

Price: $65

Abstract

Inhibitors of Rho kinase (ROCK) have many potential therapeutic applications. The biological focus of this overview will be on the role of ROCK in inflammatory disorders such as multiple sclerosis and asthma. Many ROCK inhibitors have been described in the primary and patent literature, and a diverse range of chemical scaffolds is beginning to emerge. Some of the structural classes that will be highlighted in this review include: isoquinolines, indazoles, aminofurazans, dihydropyrimidines, aminopyrimidines, benzodioxane carboxamides, benzimidazoles, and chroman amides.

Keywords: Rho-kinase (ROCK), asthma, multiple sclerosis, isoquinoline, indazole, aminofurazans, benzimidazoles, aminopyrimidine, chroman amides


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